受发育和DNA损伤应答1 (REDD1) 调控的是一种受压力引发的蛋白质，它控制着各种细胞功能，包括新陈代谢、氧化应激、自噬和细胞命运，同时也对代谢性和炎症性疾病、神经退行性疾病和癌症的发病机制起作用。REDD1通常发挥有害作用，包括肿瘤发生、代谢性炎症、神经退行性疾病和肌肉营养不良；然而，它也可以通过调控多种内在细胞活动在mTORC1依赖或非依赖机制中发挥保护功能。REDD1通常通过与14-3-3蛋白、IκBα以及硫氧还蛋白相互作用来调节mTORC1信号传导、NF-κB活化以及细胞内过氧化物或抗氧化活性。REDD1的多样功能依赖于细胞类型、细胞环境、相互作用伴侣以及细胞定位（例如线粒体，内质网或细胞质）。因此，全面了解REDD1在病理生理条件下的分子机制和生物学作用非常重要。本综述基于已发表的文献，突出并讨论了REDD1表达及其作用的分子机制、生物学功能和病理生理作用。©2023. 作者。

Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein that controls various cellular functions, including metabolism, oxidative stress, autophagy, and cell fate, and contributes to the pathogenesis of metabolic and inflammatory disorders, neurodegeneration, and cancer. REDD1 usually exerts deleterious effects, including tumorigenesis, metabolic inflammation, neurodegeneration, and muscle dystrophy; however, it also exhibits protective functions by regulating multiple intrinsic cell activities through either an mTORC1-dependent or -independent mechanism. REDD1 typically regulates mTORC1 signaling, NF-κB activation, and cellular pro-oxidant or antioxidant activity by interacting with 14-3-3 proteins, IκBα, and thioredoxin-interacting protein or 75 kDa glucose-regulated protein, respectively. The diverse functions of REDD1 depend on cell type, cellular context, interaction partners, and cellular localization (e.g., mitochondria, endomembrane, or cytosol). Therefore, comprehensively understanding the molecular mechanisms and biological roles of REDD1 under pathophysiological conditions is of utmost importance. In this review, based on the published literature, we highlight and discuss the molecular mechanisms underlying the REDD1 expression and its actions, biological functions, and pathophysiological roles.© 2023. The Author(s).