宫颈癌（CC）是第四大常见的癌症，并且是女性导致癌症相关死亡的第四大原因。在这个领域，寻找早期检测CC的新生物标志物是必不可少的要求。CXCL8最初是因其在炎症中通过与CXCR1和CXCR2结合的作用而被发现的，然而，现在人们已经知道它在癌症中发挥着重要的作用。本研究旨在评估潜在生物标志物（CXCL8、CXCR1和CXCR2）的表达水平，并探索它们在宫颈癌诊断中的潜在价值。我们采用Immulite-1000的方法对30名健康志愿者、30名癌前患者和70名宫颈癌患者的血清CXCL8、CXCR1和CXCR2的表达水平进行了研究。结果表明，与健康志愿者相比，宫颈癌患者的血清中CXCL8和CXCR2的表达显著升高，与已知的肿瘤标志物（鳞状细胞癌抗原[SCC]）相似。接受者操作特征曲线分析显示，CXCL8、CXCR2和SCC的组合具有最高的诊断敏感度和曲线下面积值。同时，其阳性预测值和阴性预测值也不低。此外，高浓度的CXCL8和CXCR2与宫颈癌的风险增加有关。综上所述，我们的数据表明，联合测量CXCL8、CXCR2和SCC的血清对于宫颈癌诊断很有帮助，并可作为早期发现宫颈癌的潜在生物标志物。细胞因子如CXCL8和CXCR2可以在大多数大学医院实验室和一些私人实验室中进行常规检测。版权归2023年作者所有。由Wolters Kluwer Health，Inc.出版。

Cervical cancer (CC) is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related death in women. Identifying new biomarkers for the early detection of CC is an essential requirement in this field. CXCL8 was originally discovered because of its role in inflammation by binding to CXCR1 and CXCR2; however, it is now known to play an important role in cancer. In this study, we aimed to evaluate the expression levels of potential biomarkers (CXCL8, CXCR1, and CXCR2) and to explore their diagnostic potential in CC.The expression levels of serum CXCL8, CXCR1, and CXCR2 were investigated by kit method on Immulite-1000 in 30 healthy volunteers, 30 precancerous patients and 70 CC patients.The results indicated that the expression of CXCL8 and CXCR2 was significantly higher in the serum of CC patients than in healthy volunteers, similar to the well-established tumor marker (squamous-cell cancerantigen [SCC]). Receiver operating characteristic analyses showed that the combination of CXCL8, CXCR2, and SCC had the highest diagnostic sensitivity and area under the curve value. Meanwhile, the positive predictive value and negative predictive value were not very low. Moreover, high concentrations of CXCL8 and CXCR2 are associated with an increased risk of CC.In conclusion, our data demonstrated that combined serum CXCL8, CXCR2, and SCC measurements are helpful for CC diagnosis and can be used as potential biomarkers for the early detection of CC. Cytokines, such as CXCL8 and CXCR2, can be easily measured in most university hospital laboratories and in some private laboratories with a routine test.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.