铁死是一种新的程序化细胞死亡类型，与其他细胞死亡途径（如凋亡、自噬、坏死和火凝死）在启动、机制和分子特征方面有所不同。由于磷脂过氧化物的积累是铁死的标志，氧化损伤和抗氧化防御之间的平衡对于限制铁死的调节机制至关重要。在癌症中，抗氧化防御通路的上调可以抑制铁死，从而促使癌细胞在氧化压力下生存并发展耐药性。本综述系统介绍了铁死的主要特征和调节机制。此外，我们总结了铁死在恶性肿瘤进展和药物耐药性中的作用，为进一步研究恶性肿瘤发病机制并开发新的抗癌治疗靶点提供了新的启示。

Ferroptosis is a new type of programmed cell death different from other cell death pathways such as apoptosis,autophagy,necrosis,and pyroptosis in terms of initiation,mechanisms,and molecular characteristics.As the accumulation of phospholipid hydroperoxides is the hallmark of ferroptosis,the balance between oxidative damage and antioxidant defense is critical to the regulatory mechanism of ferroptosis.In cancer,the upregulation of antioxidant defense pathways can inhibit ferroptosis,thereby promoting cancer cells to survive the oxidative stress and develop drug resistance.This review systematically introduces the main features and regulatory mechanisms of ferroptosis.In addition,we summarize the role of ferroptosis in the progression and drug resistance of malignant tumors,providing novel implications for further research on the pathogenesis of malignant tumors and discovery of new targets for anti-cancer therapy.