PD-L1（programmed cell death ligand 1）表达和肿瘤浸润淋巴细胞（TILs）在高级别浆液性卵巢癌（HGSOC）中的预后价值仍然是一个研究领域中有争议的话题。为了全面评估PD-L1和TILs在这个特定亚型卵巢癌中的重要性，我们进行了一项荟萃分析。我们综合搜索了PubMed、Embase、Scopus、Web of Science和Cochrane图书馆数据库，截至2022年12月25日。使用合并风险比（HR）及其对应的95%置信区间（CI）来评估PD-L1、TILs与生存预后的关联。这个荟萃分析包括了11项试验，共涉及1746例病例。结果显示肿瘤细胞（TCs）中PD-L1表达与总体生存（OS，HR=0.76，95% CI：0.52-1.09，p=0.136）或无进展生存（PFS，HR=0.71，95% CI：0.4-1.24，p=0.230）无显著关联。然而，发现PD-L1在免疫细胞（ICs）中的表达与总体生存相关（HR=0.73，95% CI：0.55-0.97，p=0.031）。此外，发现CD8+和PD-1+的TILs的存在明显提高了总体生存（HR=0.70，95% CI=0.55-0.87，p=0.002；HR=0.57，95% CI=0.40-0.80，p=0.001，分别），以及无进展生存（HR=0.62，95% CI=0.41-0.92，p=0.019；HR=0.52，95% CI=0.35-0.78，p=0.002，分别），而CD3+和CD4+的TILs的存在与总体生存呈正相关（HR=0.50，95% CI=0.29-0.87，p=0.014；HR=0.55，95% CI=0.34-0.91，p=0.020，分别）。这项研究表明ICs来源的PD-L1与生存存在正相关，并且未发现TCs来源的PD-L1与预后有显著相关性。这些结果凸显了研究ICs中PD-L1表达作为预后预测因子的重要性。此外，发现TILs的存在显著改善了患者的生存预后，这表明TILs可能是一种有价值的预后生物标记物。https://www.crd.york.ac.uk/prospero/，识别码CRD42022366411。版权所有©2023年Wang，Cai，Xue，Zhang，Zhou，Xiong和Deng。

The prognostic value of programmed cell death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSOC) remains a controversial topic in the research field. To comprehensively assess the importance of PD-L1 and TILs in this particular subtype of ovarian cancer, we performed a meta-analysis.We conducted a comprehensive search of PubMed, Embase, Scopus, Web of Science, and Cochrane Library databases up to December 25, 2022. The association between PD-L1, TILs, and survival outcomes was evaluated using the combined hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs).This meta-analysis comprised 11 trials involving a total of 1746 cases. The results revealed no significant association between PD-L1 expression in tumor cells (TCs) and overall survival (OS, HR = 0.76, 95% CI: 0.52-1.09, p = 0.136) or progression-free survival (PFS, HR = 0.71, 95% CI: 0.4 -1.24, p = 0.230). Nevertheless, a correlation was observed between PD-L1 expression in immune cells (ICs) and OS (HR = 0.73, 95% CI: 0.55-0.97, p = 0.031). Furthermore, the presence of CD8+ and PD-1+ TILs was found to significantly enhance OS (HR = 0.70, 95% CI = 0.55-0.87, p = 0.002; HR = 0.57, 95% CI = 0.40-0.80, p = 0.001, respectively) and PFS (HR = 0.62, 95% CI = 0.41-0.92, p = 0.019; HR = 0.52, 95% CI = 0.35-0.78, p = 0.002, respectively), whereas the presence of CD3+ and CD4+ TILs was positively associated with OS (HR = 0.50, 95% CI = 0.29-0.87, p = 0.014; HR = 0.55, 95% CI = 0.34-0.91, p = 0.020, respectively).This study indicates a positive correlation between ICs-derived PD-L1 and survival, while no significant correlation was observed between TCs-derived PD-L1 and prognosis. These results highlight the importance of studying PD-L1 expression in ICs as a prognostic predictor. In addition, the presence of TILs was found to significantly improve patient survival, suggesting that TILs may be a valuable prognostic biomarker.https://www.crd.york.ac.uk/prospero/, identifier CRD42022366411.Copyright © 2023 Wang, Cai, Xue, Zhang, Zhou, Xiong and Deng.