最近，三维（3D）心肌组织在研究人类心脏生物学、生理学和药理学方面引起了很大关注。器官样体作为3D迷你器官，是由多种细胞类型（诸如诱导多能干细胞（iPSCs）或胚胎干细胞（ESCs））与其他支持共培养的细胞（如内皮细胞或成纤维细胞）构建而成。心脏器官样体培养技术在器官研究方面取得了显著进展，能够建立组织再生和疾病建模。本综述提供了人类心脏器官样体平台在疾病生物学和心血管再生医学中的最新进展概述。© 2023 The Author(s).

Three-dimensional (3D) myocardial tissues for studying human heart biology, physiology and pharmacology have recently received lots of attention. Organoids as 3D mini-organs are created from multiple cell types (i.e. induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)) with other supporting co-cultured cells such as endothelial cells or fibroblasts. Cardiac organoid culture technologies are bringing about significant advances in organ research and allows for the establishment of tissue regeneration and disease modeling. The present review provides an overview of the recent advances in human cardiac organoid platforms in disease biology and for cardiovascular regenerative medicine.© 2023 The Author(s).