癌症幸存者由于日常功能受损而导致健康相关生活质量（HRQOL）降低。此外，日常压力导致氧化应激加剧。本研究旨在调查笑疗对癌症幸存者HRQOL和氧化应激的疗效。这个前后研究要求癌症幸存者在四周的时间内观看15分钟或更长时间的喜剧视频，以评估癌症综合治疗效果评估（FACT-G），欧洲五维三级评估量表（EQ-5D-3L），医院焦虑抑郁量表（HADS），生物抗氧化能力（BAP），反应性氧化代谢产物（d-ROMs），氧化应激指数（OSI）和抗氧化剂/氧化应激比率。非参数Friedman检验显示，FACT-G和EQ-VAS评分在基线值上不断增加，HADS-Anxiety和HADS-Depression评分显著下降。事后分析显示，在经过Bonferroni校正后，这些项目在基线与三周和四周后有显著差异。生物学分析的t检验结果显示小到中等效果，在BAP（p < 0.01, d = 0.49），OSI（p = 0.03, d = 0.33）和BAP/d-ROMs（p < 0.01, d = 0.51）方面有显著差异。这些结果表明，每天观看喜剧节目可能是改善癌症幸存者生活质量和抗氧化能力的有效干预措施。考虑到其安全性、便利性和低成本，应将其视为癌症幸存者的高价值干预措施。版权所有 © 2023年，Sakamoto等。

Cancer survivors have reduced health-related quality of life (HRQOL) due to impaired daily functioning. In addition, daily stress leads to worsening oxidative stress. The purpose of this study is to investigate the efficacy of laughter therapy on HRQOL and oxidative stress in cancer survivors.This before-and-after study asked cancer survivors to watch a 15-minute or longer comedy video over a four-week period to assess the Functional Assessment of Cancer Therapy-General (FACT-G), EuroQOL 5 dimension 3-level (EQ-5D-3L), Hospital Anxiety and Depression Scale (HADS), biological Antioxidant Potential (BAP), Reactive Oxygen Metabolites-derived compounds (d-ROMs), Oxidative Stress Index (OSI), and the antioxidant/oxidative stress ratio.The nonparametric Friedman test showed significant increases from baseline in FACT-G and EQ-VAS scores and significant decreases in HADS-Anxiety and HADS-Depression scores. Post hoc analyses showed that these items commonly differed significantly at baseline versus three and four weeks after Bonferroni correction. T-test results in the biological analysis revealed small and moderate effects with significant differences in BAP (p < 0.01, d = 0.49), OSI (p = 0.03, d = 0.33), and BAP/d-ROMs (p < 0.01, d = 0.51).These results suggest that daily comedy viewing may be an effective intervention to improve quality of life and antioxidant capacity in cancer survivors. Considering its safety, convenience, and low cost, it should be considered a high-value intervention for cancer survivors.Copyright © 2023, Sakamoto et al.