目前，有关便秘和抑郁之间的关联的研究还不充分。本研究旨在调查美国成年人中便秘和重度抑郁之间的详细关联。通过这项横断面研究，我们从2005年至2010年的美国国家健康和营养调查中挑选了12,352名年龄在20岁及以上的成年人作为样本。便秘被定义为每周排便次数少于三次。为了评估重度抑郁，我们使用了经验证的患者健康问卷-9进行评估。我们使用多元逻辑回归模型计算了经过调整的奥特比（ORs）。进行了次组分析以确保结果的稳定。在12,352名参与者中，有430名报告了便秘，患病率为3.5％。1030例中报告了抑郁症，表明患病率为8.3％。与无便秘的病例（7.9％）相比，便秘患者更有可能患有重度抑郁症（20.9％），差异显著（p < 0.001）。在调整了年龄、性别、种族/族裔、婚姻状况、教育水平、体重指数、积极体育活动、饮酒状况、吸烟状况、贫困收入比率、糖尿病、选择性5-羟色胺再摄取抑制剂使用、肝病、心脏病、肺病、高血压、关节炎、癌症、膳食纤维摄入、水份摄入、总脂肪摄入、碳水化合物摄入和蛋白质摄入后，便秘与重度抑郁症显著相关（OR：2.20，95％CI：1.68-2.87，p  <  0.001）。通过年龄、性别、饮食摄入、风险行为和常见并发症进行的次组分析显示没有统计学意义的交互作用（p  >  0.05）。总之，本研究表明便秘与抑郁症显著相关。在治疗患有便秘的患者时，临床医生有必要进行抑郁症的筛查和评估，并为患有抑郁症的患者提供及时和有效的干预措施，避免病情进一步恶化。 版权所有© 2023 Wang，Shen，Wang和Jia。

Current studies on the association between constipation and depression is still insufficient. In this study, we investigated the detailed association between constipation and major depression among American adults.In this cross-sectional study, 12,352 adults aged 20 and older were selected from the National Health and Nutrition Examination Survey 2005-2010 for the sample. Constipation was defined as fewer than three defecation frequencies per week. For the assessment of major depression, the validated Patient Health Questionnaire-9 was used. Adjusted odds ratios (ORs) were calculated using multivariate logistic regression models. A subgroup analysis was carried out to ensure that the results were stable.Of the 12,352 participants, 430 reported constipation, with a prevalence of 3.5%. Depression was reported in 1030 cases, indicating a prevalence rate of 8.3%. Patients with constipation were significantly more likely to have major depression (20.9%) than those without it (7.9%, p < 0.001). After adjusting for age, sex, race/ethnicity, marital status, education level, body mass index, vigorous physical activity, alcohol consumption, smoking status, poverty income ratio, diabetes, selective serotonin reuptake inhibitor use, liver disease, heart disease, pulmonary disease, hypertension, arthritis, cancer, dietary fiber intake, moisture intake, total fat intake, carbohydrates intake, and protein intake, constipation is significantly associated with major depression (OR: 2.20, 95%CI: 1.68-2.87, p < 0.001). Subgroup analyses by age, sex, dietary intake, risk behaviors, and common complications showed no statistically significant interactions (p > 0.05).In conclusion, this study showed that constipation were significantly associated with depression. When treating patients with constipation, it is necessary for clinicians to screen and evaluate depression, and provide timely and effective intervention for patients with depression to avoid further deterioration of the condition.Copyright © 2023 Wang, Shen, Wang and Jia.