波伊斯厚皮阿魏（Ferula gummosa Boiss）是一种著名的伊朗特有植物，被用于伊朗传统医药治疗各种疾病。本研究旨在评估厚皮阿魏胶对前列腺癌PC-3细胞的抗氧化和细胞毒性能力。本研究评估了胶的总酚和黄酮含量以及抗氧化潜力。MTT实验用于评估胶对PC-3细胞的细胞毒性潜力。通过克隆形成、微核形成和乳酸丹/溴乙酸乙腈染色法评估PC-3细胞的存活和增殖情况。DNA降解和caspase 3/7活性评估用于评估细胞凋亡。通过体外划痕愈合实验检测对PC-3细胞迁移的抑制作用。胶的总酚和黄酮含量分别为9.22 mg GAE/g和3.6 mg QE/g（相对于没食子酸和槲皮素），抗氧化潜力为13 μg/ml（p <0.05）。48小时的IC50值为9.14 μg/ml（相对于未处理细胞）（p <0.01）。DNA降解模式和caspase 3/7活性水平（相对于未处理细胞）（p <0.05）表明细胞存活率降低可能是由于凋亡诱导造成的。显微观察结果显示，在处理为8和10 μg/ml胶的PC-3细胞中，出现了细胞核浓缩、微核生成显著增加和形成菌落的抑制（相对于未处理细胞）（p <0.01）。划痕愈合评估显示了胶的迁移抑制潜力（相对于未处理细胞）（p <0.05）。这些结果表明，波伊斯厚皮阿魏具有显著的抗氧化和细胞毒性特性，使其成为进一步研究的良好候选者。

Ferula gummosa Boiss is a well-known Iranian endemic plant that has been used in Iranian traditional medicine against various diseases. This study aimed to evaluate the antioxidant and cytotoxic capacity of F. gummosa gum on prostate cancer PC-3 cells.In this study, we evaluated the total phenolic and flavonoid contents, and antioxidant potentials of the gum. The MTT experiment was conducted to assess the cytotoxic potential of the gum on PC-3 cells. The clonogenic, micronucleus formation, and acridine orange/ethidium bromide staining methods were used to evaluate the survival and proliferation of PC-3 cells. DNA degradation and caspase 3/7 activity evaluations were used to assess apoptosis. The inhibitory effect on the migration of PC-3 cells was examined by in vitro wound-healing experiment.Total phenolic and flavonoid contents, and antioxidant potential of the gum were 9.22 mg of gallic acid equivalent (GAE)/g, 3.6 mg of quercetin equivalents (QE) /g of the extract, and 13 μg/ml, respectively (compared to gallic acid and quercetin, respectively) (p<0.05). The IC50 value was 9.14 µg/ml for 48 hours (compared to non-treated cells) (p<0.01). The pattern of DNA degradation, and caspase 3/7 activity levels (compared to non-treated cells) (p<0.05) proposed decreased cell viability that may be due to apoptosis induction. Microscopic observations revealed nuclear condensation, a significant increase in the formation of micronuclei, and inhibition of forming colonies (compared to non-treated cells) (p<0.01) in PC-3 cells treated with 8 and 10 μg/ml of the gum. Wound-healing assessment showed the migration suppression potentials of the gum (compared to non-treated cells) (p<0.05).These results indicate that F. gummosa has considerable antioxidant and cytotoxic properties that can make it a good nominee for subsequent investigations.