控制可避免的癌症原因可以节省癌症相关的医疗费用、过早死亡和生产力损失的间接费用。本研究旨在估计2015年日本由主要的生活方式和环境风险因素导致的癌症的经济负担。我们从社会角度评估了可修改的风险因素所致癌症的经济成本。我们从日本国家健康保险申诉数据库和特定健康检查处获得了2015年的直接医疗费用，并使用日本相关的国家调查估计了由于癌症导致的过早死亡和疾病负担的间接费用。最后，我们估计了与生活方式和环境风险因素相关的癌症的经济成本。估计的与生活方式和环境因素相关的癌症的成本为1,024,006亿日元（¥）（84.6亿美元[$]），男性为673,780亿日元（56.6亿美元），女性为350,226亿日元（28.93亿美元），使用2015年的平均汇率（1美元=121.044日元）。2015年日本因过早死亡而损失了285,150亿日元（23.56亿美元）。估计可预防的间接发病率成本为200,602亿日元（16.57亿美元）。生产力损失在男性胃癌（28,735亿日元/2.37亿美元）和女性宫颈癌（24,448亿日元/2.02亿美元）中最高。预防和控制由幽门螺杆菌、人乳头瘤病毒和吸烟等感染引起的癌症不仅可以挽救生命，而且从长远来看也可能节省费用。2023年，国立全球健康与医学中心。

Controlling avoidable causes of cancer may save cancer-related healthcare costs and indirect costs of premature deaths and productivity loss. This study aimed to estimate the economic burden of cancer attributable to major lifestyle and environmental risk factors in Japan in 2015. We evaluated the economic cost of cancer attributable to modifiable risk factors from a societal perspective. We obtained the direct medical costs for 2015 from the National Database of Health Insurance Claims and Specific Health Checkups of Japan, and estimated the indirect costs of premature mortality and of morbidity due to cancer using the relevant national surveys in Japan. Finally, we estimated the economic cost of cancer associated with lifestyle and environmental risk factors. The estimated cost of cancer attributable to lifestyle and environmental factors was 1,024,006 million Japanese yen (¥) (8,460 million US dollars [$]) for both sexes, and ¥673,780 million ($5,566 million) in men and ¥350,226 million ($2,893 million) in women, using the average exchange rate in 2015 ($1 = ¥121.044). A total of ¥285,150 million ($2,356 million) was lost due to premature death in Japan in 2015. Indirect morbidity costs that could have been prevented were estimated to be ¥200,602 million ($1,657 million). Productivity loss was highest for stomach cancer in men (¥28,735 million/$237 million) and cervical cancer in women (¥24,448 million/$202 million). Preventing and controlling cancers caused by infections including Helicobacter pylori, human papillomavirus and tobacco smoking will not only be life-saving but may also be cost-saving in the long run.2023, National Center for Global Health and Medicine.