研究动态
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胰腺癌中多功能GQDs的受体靶向、药物传递和生物成像

Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer.

发表日期:2023 Sep 01
作者: Monu Kumar Shukla, Arpana Parihar, Chandrabose Karthikeyan, Deepak Kumar, Raju Khan
来源: Cellular & Molecular Immunology

摘要:

胰腺癌是一种破坏性的疾病,生存率低,治疗选择有限。由于其卓越的物理化学性质,如生物相容性、稳定性和荧光特性,石墨烯量子点(GQDs)最近成为了作为癌症诊断和治疗的有希望平台而备受关注。本综述讨论了多功能GQDs作为胰腺癌受体靶向、药物传递和生物成像平台的潜力。目前的研究强调了GQDs通过过表达细胞表面结合受体选择性靶向胰腺癌细胞的能力。此外,本综述讨论了GQDs作为药物传递载体,用于对胰腺癌细胞进行受控和靶向释放治疗物的用途。最后,本综述讨论了GQDs作为胰腺癌检测和监测的成像试剂的潜力。总体而言,多功能GQDs作为诊断和治疗胰腺癌的多用途平台表现出巨大潜力。进一步研究多功能GQDs在胰腺癌治疗方面的潜力和优化是必要的。
Pancreatic cancer is a devastating disease with a low survival rate and limited treatment options. Graphene quantum dots (GQDs) have recently become popular as a promising platform for cancer diagnosis and treatment due to their exceptional physicochemical properties, such as biocompatibility, stability, and fluorescence. This review discusses the potential of multifunctional GQDs as a platform for receptor targeting, drug delivery, and bioimaging in pancreatic cancer. The current studies emphasized the ability of GQDs to selectively target pancreatic cancer cells by overexpressing binding receptors on the cell surface. Additionally, this review discussed the uses of GQDs as drug delivery vehicles for the controlled and targeted release of therapeutics for pancreatic cancer cells. Finally, the potential of GQDs as imaging agents for pancreatic cancer detection and monitoring has been discussed. Overall, multifunctional GQDs showed great promise as a versatile platform for the diagnosis and treatment of pancreatic cancer. Further investigation of multifunctional GQDs in terms of their potential and optimization in the context of pancreatic cancer therapy is needed.