针对癌症的威胁，Ca2+信号传导工具箱目前正受到调查作为潜在的治疗靶点。越来越多的证据表明，钙信号传导在促进癌症的各个方面起着关键作用，包括细胞增殖、进展、耐药性和迁移相关活动。因此，专注于这些改变的Ca2+转运蛋白已成为癌症治疗的一项有前途的研究领域。本综述重点介绍了Ca2+转运蛋白在癌症进展中的作用的现有研究。它讨论了当前研究评估Ca2+通道/转运体/泵阻断剂、抑制剂或调节剂作为潜在抗癌药物的研究。此外，本综述还提及了我们对该领域理解的特定差距可能需要进一步研究。针对特定的Ca2+信号级联可能会干扰正常细胞活动，使癌症治疗变得复杂和难以捉摸。因此，目前的Ca2+信号通路相关药物需要改进。虽然合成分子和植物化合物显示出潜力，但它们也存在一定的局限性。因此，探索以靶向药物输送、基于结构合理性设计和重用潜在药物等为基础，针对Ca2+转运蛋白可能会有重大突破癌症治疗的潜力。

The Ca2+ signaling toolkit is currently under investigation as a potential target for addressing the threat of cancer. A growing body of evidence suggests that calcium signaling plays a crucial role in promoting various aspects of cancer, including cell proliferation, progression, drug resistance, and migration-related activities. Consequently, focusing on these altered Ca2+ transporting proteins has emerged as a promising area of research for cancer treatment.This review highlights the existing research on the role of Ca2+-transporting proteins in cancer progression. It discusses the current studies evaluating Ca2+ channel/transporter/pump blockers, inhibitors, or regulators as potential anticancer drugs. Additionally, the review addresses specific gaps in our understanding of the field that may require further investigation.Targeting specific Ca2+ signaling cascades could disrupt normal cellular activities, making cancer therapy complex and elusive. Therefore, there is a need for improvements in current Ca2+ signaling pathway focused medicines. While synthetic molecules and plant compounds show promise, they also come with certain limitations. Hence, exploring the framework of targeted drug delivery, structure-rationale-based designing, and repurposing potential drugs to target Ca2+ transporting proteins could potentially lead to a significant breakthrough in cancer treatment.