槲皮素是一种具有有望治疗应用的类黄酮类化合物；然而，在某些疾病中所表现的表型是相互矛盾的。例如，抗癌特性可以通过细胞毒性机制来解释，而与抗氧化相关的神经保护是一种促进细胞生存的过程。根据现有文献，槲皮素在线粒体中与电子传递链（ETC）发生氧化还原反应，对其膜电位产生影响。它还影响通过氧化磷酸化来产生ATP，其中ATP缺乏可能部分解释了其细胞毒性作用。此外，槲皮素可能通过氧化还原反应促进自由基的产生，产生一种氧化剂的效果。槲皮素引起的营养应激和氧化剂作用可能促进了抗氧化过程等促进细胞生存的特性。因此，在本综述中，我们讨论了证据，支持槲皮素与ETC的氧化还原相互作用能够解释其有益和有毒特性。© 2023. 作者，独家授权给施普林格科学+商业媒体有限责任公司，施普林格自然出版集团的一部分。

Quercetin is a flavonoid with promising therapeutic applications; nonetheless, the phenotype exerted in some diseases is contradictory. For instance, anticancer properties may be explained by a cytotoxic mechanism, whereas antioxidant-related neuroprotection is a pro-survival process. According to the available literature, quercetin exerts a redox interaction with the electron transport chain (ETC) in the mitochondrion, affecting its membrane potential. It also affects ATP generation by oxidative phosphorylation, where ATP deprivation could partly explain its cytotoxic effect. Moreover, quercetin may support the generation of free radicals through redox reactions, causing a prooxidant effect. The nutrimental stress and prooxidant effect induced by quercetin might promote pro-survival properties such as antioxidant processes. Thus, in this review, we discuss the evidence supporting that quercetin redox interaction with the ETC could explain its beneficial and toxic properties.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.