真菌病与高发病率和死亡率相关联，然而其流行病学和负担问题尚未得到很好的解决。尽管死亡人数可能超过每年150万人，但很多病例仍然未被诊断和报道。为了优先考虑和实施有效的控制计划，需要估计这些疾病的负担。本研究利用以风险群体为基础的模型，估计苏丹严重真菌感染的负担。通过文献获得了包括HIV、结核病、癌症、哮喘和慢性阻塞性肺疾病在内的易感人群的患病率。使用本地数据计算真菌感染的发病率和患病率，如果无相关数据，则使用区域或国际数据。总共，估计苏丹患有真菌病的人数为500万（占总人口的10%）。估计头癣患者为4,127,760例，复发性阴道炎和角膜炎分别为631,261例和6,552例。HIV相关的真菌感染估计患有5,945例口腔念珠菌病、1,921例食道念珠菌病、571例肺囊虫肺炎和462例隐球菌脑膜炎。曲霉感染估计情况如下：3,438例侵袭性曲霉症，14,950例慢性肺曲霉病，67,860例过敏性支气管肺曲霉症，而严重哮喘伴真菌致敏和真菌性鼻窦炎的患病率分别为86,860例和93,600例。被忽视的热带病真菌痣估计影响16,837例，患病率为36/10万。在苏丹，严重真菌感染相当普遍，需要紧急关注改善诊断、推广治疗和开展监测计划的问题。版权：© 2023 Ahmed等人。本文为开放获取文章，根据知识共享署名许可证发布，可以无限制地使用、分发和再制作，前提是原作者和来源得到了著作权的确认。

Fungal diseases are associated with high morbidity and mortality, yet their epidemiology and burden are not well addressed. While deaths probably exceed 1.5 million per year, many cases remain undiagnosed and underreported. Estimating the burden of these diseases is needed for prioritization and implementation of effective control programs. Here we used a model based on population at risk to estimate the burden of serious fungal infections in Sudan. The prevalence of the susceptible population including HIV, TB, cancer, asthma, and COPD was obtained from the literature. Incidence and prevalence of fungal infections were calculated using local data when applicable and if not available then regional or international figures were used. In total, the estimated number of Sudanese suffering from fungal disease is 5 M (10% of the total population). Tinea capitis, recurrent vulvovaginitis and keratitis are estimated to affect 4,127,760, 631,261, and 6,552 patients, respectively. HIV-related mycosis is estimated to affect 5,945 oral candidiasis, 1,921 esophageal candidiasis, 571 Pneumocystis pneumonia, and 462 cryptococcal meningitis cases. Aspergillus infections are estimated as follow: 3,438 invasive aspergillosis, 14,950 chronic pulmonary aspergillosis, 67,860 allergic bronchopulmonary aspergillosis cases, while the prevalence of severe asthma with fungal sensitization and fungal rhinosinusitis was 86,860 and 93,600 cases, respectively. The neglected tropical disease eumycetoma was estimated to affect 16,837 cases with a rate of 36/100,000. Serious fungal infections are quite common in Sudan and require urgent attention to improve diagnosis, promote treatment, and develop surveillance programs.Copyright: © 2023 Ahmed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.