半夏泻心汤（BXD）是一种由半夏、生姜、黄芩、黄连、人参、大枣和炙甘草为主要药材组成的著名中草药方剂，具有辛开、苦降和甘补的显著特点，对肿瘤、胃肠道疾病、中枢神经系统疾病等有干预作用。在广泛的临床应用基础上，目前对于BXD的研究主要集中在以下几个方面：通过化学分析探索其治疗效果的潜在物质基础；对整个处方或具有代表性的成分进行药理学研究，揭示其特定病理过程的有趣分子靶点；对BXD的单个或全部成分进行药代动力学特性研究，揭示其药理学和临床治疗效果的化学基础和协同作用。在本综述中，我们总结了BXD及其草药或药理活性成分的植物化学、药理学、临床和药代动力学概况，并对我们的认识进行了讨论，进一步揭示了BXD在临床中的重要意义。版权所有 © 2023 作者。由 Wolters Kluwer Health, Inc. 发表。

Banxia Xiexin decoction (BXD), a famous traditional Chinese prescription constituted by Pinelliae Rhizoma, Zingiberis Rhizoma, Scutellariae Radix, Coptidis Rhizoma, Ginseng Radix et Rhizoma, Jujubae Fructus and Glycyrrhizae Radix et Rhizoma Praeparata Cum Mell, has notable characteristics of acrid-opening, bitter down-bearing and sweet-tonification, interfering with tumors, gastrointestinal diseases, central nervous system diseases and much more. Based on the wide clinical applications, current investigations of BXD focused on several aspects: chemical analysis to explore the underlying substrates responsible for the therapeutic effects; basic studies on pharmacological actions of the whole prescription or of those representative ingredients to demonstrate the intriguing molecular targets for specific pathological processes; pharmacokinetic feature studies of single or all components of BXD to reveal the chemical basis and synergistic actions contributing to the pharmacological and clinically therapeutic effects. In this review, we summarized the main achievements of phytochemical, pharmacological, clinical and pharmacokinetic profiles of BXD and its herbal or pharmacologically active chemicals, as well as discussions of our understanding which further reveals the significance of BXD clinically.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.