在过去的十年中，“微芯片器官”或“器官样品微物理分析平台（MAP）”已引起人们对疾病模型、药物发现和发育生物学实际应用的关注。由于伦理问题，对孕妇进行研究具有明确限制，因此通过疾病重塑或药物监测，在体外重建人类妊娠对于治疗途径的开发非常有益。本综述重点介绍了生物工程器件在重现人类妊娠方面的当前努力，并强调了生物学、工程学和母婴医学的重要交汇。首先，我们回顾了最新的从涉及妊娠的组织中培养细胞的成就，尤其是胎盘滋养层细胞。其次，我们突出了在多个结构和功能解读上重构与妊娠相关的女性生殖器官的发展。最后，我们研究了与妊娠相关疾病的基本理解，以寻找生物工程解决方案。通过工程模型再现人类妊娠的过程自然而然地很复杂；然而，挑战在于推进精准医学的过程中是不可避免的。版权所有 © 2023 The Author(s). Elsevier B.V. 发布，保留所有权利。

During the last decade, organs-on-chips or organoids microphysiological analysis platforms (MAP) have garnered attention in the practical applications of disease models, drug discovery, and developmental biology. Research on pregnant women has firm limitations due to ethical issues; thus, remodelling human pregnancy in vitro is highly beneficial for treatment modality development via disease remodelling or drug monitoring. This review highlights current efforts in bioengineering devices to reproduce human pregnancy and emphasises the significant convergence of biology, engineering, and maternal-foetal medicine. First, we review recent achievements in culturing cells from tissues involved in pregnancy; specifically, trophoblasts from the placenta. Second, we highlight developments in the reconstitution of pregnancy-related female reproductive organs across several structural and functional interpretations. Last, we examine research on the fundamental comprehension of pregnancy-associated diseases to find bioengineering solutions. Recreating human pregnancy through an engineered model is naturally complex; nevertheless, challenges are inevitable to progress precision medicine.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.