肺腺癌（LUAD）是非小细胞肺癌中最常见的亚型。另外，一种新近发现的细胞死亡类型，二硫酸异丙酯症（disulfidptosis）被发现与肿瘤的发生和发展密切相关。本研究首先通过相关性分析鉴定了与二硫酸异丙酯症相关的基因。然后，使用单变量Cox回归和LASSO回归对这些基因进行筛选，并通过多因素Cox回归构建了预后模型。此外，我们还创建了一个预后评估图（nomogram）用于预测LUAD的预后。该模型在独立的三个数据集（GSE72094、GSE31210和GSE37745）中进行了验证。接下来，我们将患者根据其中位风险评分分组，并分析了两组之间的差异表达基因。此外，我们还进行了富集分析、免疫浸润分析和药物敏感性评估。 本研究检测了与二硫酸异丙酯症相关的21个基因，并开发了一个基因签名，与LUAD的预后不良有关。通过三个独立数据集验证了我们的模型，并显示出1、3和5年的AUC值大于0.5。富集分析揭示了与二硫酸异丙酯症相关的基因签名对LUAD产生了多方面的影响，尤其是与肿瘤发展、增殖和转移有关。高风险组患者显示出更高的肿瘤纯度和较低的基质评分、ESTIMATE评分和免疫评分。 本研究构建了与肺腺癌相关的二硫酸异丙酯症基因签名，并分析了其对疾病的影响及其与肿瘤微环境的关联。这些研究结果为理解肺腺癌提供了宝贵的见解，并有可能带来新的治疗策略的开发。 版权所有 © 2023 作者。Elsevier Ltd.保留所有权利。

Lung adenocarcinoma (LUAD) is the most prevalent subtype of non-small cell lung cancer. Additionally, disulfidptosis, a newly discovered type of cell death, has been found to be closely associated with the onset and progression of tumors.The study first identified genes related to disulfidptosis through correlation analysis. These genes were then screened using univariate cox regression and LASSO regression, and a prognostic model was constructed through multivariate cox regression. A nomogram was also created to predict the prognosis of LUAD. The model was validated in three independent data sets: GSE72094, GSE31210, and GSE37745. Next, patients were grouped based on their median risk score, and differentially expressed genes between the two groups were analyzed. Enrichment analysis, immune infiltration analysis, and drug sensitivity evaluation were also conducted.In this study, we examined 21 genes related to disulfidptosis and developed a gene signature that was found to be associated with a poorer prognosis in LUAD. Our model was validated using three independent datasets and showed AUC values greater than 0.5 at 1, 3, and 5 years. Enrichment analysis revealed that the disulfidptosis-related genes signature had a multifaceted impact on LUAD, particularly in relation to tumor development, proliferation, and metastasis. Patients in the high-risk group exhibited higher tumor purity and lower stromal score, ESTIMATE score, and Immune score.This study constructed a gene signature related to disulfidptosis in lung adenocarcinoma and analyzed its impact on the disease and its association with the tumor microenvironment. The findings of this research provide valuable insights into the understanding of lung adenocarcinoma and could potentially lead to the development of new treatment strategies.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.