之前，研究关注于葡萄糖以外单糖在癌症中的调节作用和临床应用是被忽视的。甘露糖是一种常见的单糖，在人体体液和组织中广泛存在，其主要功能是参与蛋白质糖基化而不是碳水化合物代谢。最近的研究表明，甘露糖在体外和体内直接具有抗癌作用。通过简单地向细胞培养基或饮用水中补充甘露糖就能达到这些效果。此外，甘露糖还能增强目前的癌症治疗方法，包括化疗、放疗、靶向治疗和免疫疗法的有效性。除了在甘露糖的抗癌效应的基础研究方面的进展，最近的研究还报道了甘露糖作为癌症生物标志物以及使用甘露糖修饰的药物传递系统来传递抗癌药物的应用。本综述讨论了对甘露糖在癌症进展中调节作用的认识的进展，其抗癌作用的机制以及它在癌症诊断和治疗方面的应用。版权所有 © 2023. Elsevier B.V. 发布。

Studies examining the regulatory roles and clinical applications of monosaccharides other than glucose in cancer have been neglected. Mannose, a common type of monosaccharide found in human body fluids and tissues, primarily functions in protein glycosylation rather than carbohydrate metabolism. Recent research has demonstrated direct anticancer effects of mannose in vitro and in vivo. Simply supplementing cell culture medium or drinking water with mannose achieved these effects. Moreover, mannose enhances the effectiveness of current cancer treatments including chemotherapy, radiotherapy, targeted therapy, and immune therapy. Besides the advancements in basic research on the anticancer effects of mannose, recent studies have reported its application as a biomarker for cancer or in the delivery of anticancer drugs using mannose-modified drug delivery systems. This review discusses the progress made in understanding the regulatory roles of mannose in cancer progression, the mechanisms underlying its anticancer effects, and its current application in cancer diagnosis and treatment.Copyright © 2023. Published by Elsevier B.V.