生命的最后一个月内进行放射治疗与生命末期的过度护理存在关联。
Radiation therapy in the last month of life. Association with Aggressive Care at the End of Life.
发表日期:2023 Aug 30
作者:
Mellar P Davis, Erin Vanenkevort, Amanda Young, Mark Wojtowicz, Mudit Gupta, Braxton Lagerman, Edward Liu, Heath Mackley, Rajiv Panikkar
来源:
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
摘要:
癌症患者中一半接受放射疗法是出于姑息治疗的目的。研究病人特征、癌症进展情况、放疗类型和时长、是否接受姑息治疗以及放射疗法与侵入性癌症护理指标的关系,以确定在生命的最后一个月内接受放射疗法的比例。纳入了2018年1月1日至2019年12月31日间逝世的1727名癌症患者。收集了人口统计学数据、癌症分期、姑息治疗转诊、预先指示、家庭护理使用情况、放疗时间和生存状况。回顾了放疗类型、过程和目的。对分类变量使用卡方分析,对连续变量使用Kruskal-Wallis检验。采用逐步选择建立Cox比例风险模型。233名患者在生命的最后一个月接受了放射疗法。年轻患者接受放射疗法的年龄为67.3岁(标准差11.52),而非接受放射疗法的年龄为69.2岁(标准差11.96)。42.6%的患者在死亡前两周接受放疗。平均治疗次数为5.5次。接受放射疗法的患者更有可能在生命的最后30天开始化疗,在死亡前两周继续化疗,入住重症监护室,并有两次或更多次住院或急诊就诊。从诊断日起的生存期,在接受放射疗法的患者中较短,为122天(四分位数范围58-462),而在非接受放射疗法的患者中为474天(四分位数范围225-1150)。在接受放射疗法的患者中,姑息治疗会较晚进行。在生命的最后一个月内接受放射疗法主要发生在年轻、癌症进展迅速、接受更侵入性癌症护理、姑息治疗咨询较晚的患者。版权所有 © 2023 Elsevier Inc. 发布.
Half of the patients with cancer who undergo radiation therapy do so with palliative intent.To determine the proportion of undergoing radiation in the last month of life, patient characteristics, cancer course, the type and duration of radiation, whether palliative care was involved, and the of radiation with aggressive cancer care metrics.1727 patients who died of cancer between January 1, 2018, and December 31, 2019, were included. Demographics, cancer stage, palliative care referral), advance directives, use of home health care, radiation timing, and survival were collected. Type of radiation, course and intent were reviewed. Chi-square analysis was utilized for categorical variables, and Kruskal-Wallis tests for continuous variables. A stepwise selection was used to build a Cox proportional hazard model.233 patients underwent radiation in the last month of life. Younger patients underwent radiation 67.3 years (SD 11.52) versus 69.2 years (SD 11.96). 42.6% had radiation within 2 weeks of death. The average fraction number was 5.5. Individuals undergoing radiation were more likely to start chemotherapy within the last 30 days of life, continue chemotherapy within 2 weeks of death, be admitted to the ICU, and have two or more hospitalizations or emergency room visits. Survival measured from the date of diagnosis was shorter for those undergoing radiation, 122 days (IQR 58-462) versus 474 days (IQR 225-1150). Palliative care consultations occurred later in those undergoing radiation therapy.Radiation therapy in the last month of life occurs in younger patients with rapidly progressive cancer, who are subject to more aggressive cancer care, and have late palliative care consults.Copyright © 2023. Published by Elsevier Inc.