副皮肤T细胞淋巴瘤（CTCL）是一种影响皮肤的癌症，其特征是皮肤中异常的T细胞。表观遗传学变化已被发现在CTCL的发展和进展中起重要作用。最近，非编码RNA（ncRNA），如microRNA和长非编码RNA，被确定为CTCL基因表达调控的关键因子。这些ncRNA可以改变涉及细胞生长、分化和凋亡的基因的表达，导致CTCL的发展和进展。在本综述中，我们总结了ncRNA在CTCL中的作用的现有理解，包括它们在DNA甲基化和其他生物学过程中的参与。我们还讨论了ncRNA的类型，它们作为致癌或肿瘤抑制因子以及根据实验室和患者研究得出的推测性诊断和预后标志物的使用。此外，我们还介绍了受ncRNA影响的潜在靶点和通路。更好地理解CTCL的复杂表观遗传学环境，包括ncRNA的作用，有可能为该疾病的新靶向治疗的开发铺平道路。版权所有 © 2023 Elsevier Inc. 发布。

Cutaneous T-cell lymphoma (CTCL) is a type of cancer that affects skin, and is characterized by abnormal T-cells in the skin. Epigenetic changes have been found to play a significant role in the development and progression of CTCL. Recently, non-coding RNAs (ncRNAs), such as microRNAs and long non-coding RNAs, have been identified as key players in the regulation of gene expression in CTCL. These ncRNAs can alter the expression of genes involved in cell growth, differentiation, and apoptosis, leading to the development and progression of CTCL. In this review, we summarize the current understanding of the role of ncRNAs in CTCL, including their involvement in DNA methylation, and other biological processes. We also discuss the types of ncRNAs, their role as oncogenic or tumor suppressive, and their putative use as diagnostic and prognostic biomarkers, based on the emerging evidence from laboratory-based as well as patients-based studies. Moreover, we also present the potential targets and pathways affected by ncRNAs. A better understanding of the complex epigenetic landscape of CTCL, including the role of ncRNAs, has the potential to lead to the development of novel targeted therapies for this disease.Copyright © 2023. Published by Elsevier Inc.