干扰素信号限制肾细胞癌的异质性。
Interferon signaling restrains renal cell carcinoma heterogeneity.
发表日期：2023 Aug 30
作者：
Peter Holicek, Jitka Fucikova, Lorenzo Galluzzi
来源：
Stem Cell Research & Therapy
摘要：
一型干扰素（IFN）在癌症监测中起着重要作用，因为它介导了直接和免疫介导的抑制肿瘤效应。Perelli等人最近的研究表明，肾癌细胞能够容忍由染色体不稳定性（CIN）引发的复杂核型改变，并最终获得完全的转移潜力，这也受到IFN信号的负调控。版权所有© 2023 Elsevier Inc.保留所有权利。
Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.Copyright © 2023 Elsevier Inc. All rights reserved.