铁死亡是一种以铁依赖性磷脂过氧化和活性氧物质过量产生为特征的细胞死亡类型。铁死亡引发免疫原性细胞死亡，并诱导抗肿瘤免疫反应，在癌症免疫治疗中扮演重要角色。铁死亡在癌细胞中的抑制削弱了其免疫治疗的功效。为了克服这个问题，铁死亡诱导剂（FINs）已经与其他癌症治疗方法结合，以创建抗肿瘤的免疫微环境。然而，铁死亡基于免疫和肿瘤细胞之间的相互作用非常复杂，因为铁死亡的肿瘤细胞释放的氧化产物损害了抗肿瘤免疫细胞的功能，导致免疫治疗的抵抗性。在本文中，我们回顾了肿瘤和免疫细胞中的铁死亡，并总结了铁死亡肿瘤细胞与免疫微环境之间的相互作用。根据现有文献，我们进一步讨论了将铁死亡靶向治疗与癌症免疫治疗结合的未来展望。版权所有©2023 Elsevier Ltd.发表

Ferroptosis is a type of cell death characterized by iron-dependent phospholipid peroxidation and reactive oxygen species overproduction. Ferroptosis induces immunogenic cell death and elicits anti-tumor immune responses, playing an important role in cancer immunotherapy. Ferroptosis suppression in cancer cells impairs its immunotherapeutic efficacy. To overcome this issue, ferroptosis inducers (FINs) have been combined with other cancer therapies to create an anti-tumor immune microenvironment. However, the ferroptosis-based crosstalk between immune and tumor cells is complex because oxidative products released by ferroptotic tumor cells impair the functions of anti-tumor immune cells, resulting in immunotherapeutic resistance. In the present article, we have reviewed ferroptosis in tumor and immune cells and summarized the crosstalk between ferroptotic tumor cells and the immune microenvironment. Based on the existing literature, we have further discussed future perspectives on opportunities for combining ferroptosis-targeted therapies with cancer immunotherapies.Copyright © 2023. Published by Elsevier Ltd.