前列腺癌是男性最常见的恶性肿瘤之一，被视为公共健康威胁。KIF15是一种驱动蛋白，其异常表达与恶性肿瘤的发生和发展密切相关。本研究的目的是探讨KIF15在前列腺癌中的意义和作用，并展示其在前列腺癌中的潜在价值。免疫组化分析显示，KIF15在前列腺癌组织中高度表达，并与T细胞浸润呈正相关。基于前列腺癌细胞的失活和增活实验表明，KIF15表达的改变可显著影响细胞增殖、肿瘤发生、迁移和细胞凋亡。在体实验证实了通过KIF15敲除可以抑制前列腺癌发展。人类凋亡抗体芯片显示，在KIF15敲除后，CD40L、细胞色素C、DR6和p21上调，IGF-I和Survivin下调。此外，初步证明了PI3K/Akt通路在KIF15介导的前列腺癌调控中的参与。总结起来，我们确定KIF15在前列腺癌的发展或生物进程中发挥了重要作用，并被认为具有作为治疗靶点的潜力。© 2023. 细胞死亡与分化协会 (ADMC)。

Prostate cancer is one of the most common malignancies in men, which has been considered a public health threat. KIF15 is a kind of driver protein, and its abnormal expression is closely related to the occurrence and development of malignant tumors. The purpose of the study was to explore the significance and role of KIF15 in prostate cancer and to show some potential value for prostate cancer. Immunohistochemistry analysis showed that KIF15 was highly expressed in prostate cancer tissues, which was also positively correlated with T Infiltrate. The loss-of-function and gain-of-function assays based on prostate cancer cells indicated that the change in KIF15 expression could significantly affect cell proliferation, tumorigenesis, migration, and cell apoptosis. The inhibition of prostate cancer development by KIF15 knockdown was also assured in vivo. The Human Apoptosis Antibody Array showed that CD40L, cytoC, DR6, and p21 were up-regulated upon KIF15 knockdown, while IGF-I and Survivin were down-regulated. Moreover, the involvement of the PI3K/Akt pathway in the KIF15-mediated regulation of prostate cancer was preliminarily proved. In summary, KIF15 was identified to play an important role in the development or biological progress of prostate cancer and is considered to possess the potential to be used as a therapeutic target.© 2023. Cell Death Differentiation Association (ADMC).