卵巢癌是妇科癌症相关死亡的主要原因之一。CD117是一种酪氨酸激酶受体，通过结合其配体干细胞因子，在调节细胞凋亡、细胞增殖和细胞黏附方面发挥重要作用。最近的研究表明，在各种恶性肿瘤中CD117的异常高表达，并且认为它可能在癌变过程中起关键作用。为了评估CD117在卵巢面上皮肿瘤中的表达情况，本回顾性研究包括30个卵巢上皮边缘性、低度恶性和高度恶性肿瘤的福尔马林固定石蜡块（FFPE）组织块。对组织切片进行常规苏木精-伊红染色，并用抗CD117免疫组化染色。在CD117的表达方面，边缘性和恶性组之间存在极显著差异（P = 0.001）。此外，在低级别和高级别卵巢面上皮肿瘤的组织学类型（浆液型与非浆液型）方面，表达也存在显著差异（p=0.04, p=0.035）。肿瘤的分级和分期与CD117的表达强烈相关（p=0.014, p=0.019）。我们得出结论，CD117的表达与较高的卵巢肿瘤分级和分期显著相关。

Ovarian cancer is one of leading causes of cancer related death in gynecology. CD117 is a tyrosine kinase receptor that plays an important role in regulation of apoptosis, cell proliferation and adhesion by binding to its ligand-stem cell factor. Recent studies demonstrated its aberrant overexpression in various malignancies and concluded that it may play a pivotal role in carcinogenesis.To evaluate CD117 expression in ovarian surface epithelial tumours.This retrospective study included 30 ovarian epithelial borderline, low and highly malignant tumours' formalin-fixed paraffin-blocks (FFPE) tissue blocks. Tissue sections were subjected to the routine haematoxylin-eosin stain and with the anti-CD117 immunohistochemically.There is a high significant difference in CD117 expression between borderline and malignant groups (P = 0.001). Additionally, there was significant difference in expression in relation to histopathological type (serous versus non-serous) in low-grade and the high-grade ovarian surface epithelial tumours (p=0.04, p=0.035 respectively). Tumour grade and stage strongly correlates with CD117 expression (p=0.014, p=0.019 respectively).We concluded that CD117 expression was significantly correlated with higher ovarian tumour grade and stage.