有证据表明，使用个性化基因组风险提供和基因咨询的黑色素瘤预防计划可以影响预防行为，包括减少无黑色素瘤病史的成年人晒伤。该分析从澳大利亚卫生系统的角度评估了其较长期的费用效益。主要结果是基因组风险提供（干预组）与标准预防建议之间的增量成本效益比（ICER）。采用决策分析的Markov模型，使用随机试验数据进行终身费用效益模拟。所有费用以2018/19年澳大利亚元（AUD）呈现。针对性干预对减少晒伤的效果按性别和传统风险分层，通过经过验证的预测模型计算。进行确定性和概率敏感性分析以进行鲁棒性检查。干预的每个参与者的费用为189澳大利亚元。针对高传统风险个体的基因组风险提供产生了AUD$35,254的ICER（每获得一QALY的成本）；敏感性分析表明在超过50％的情况下，该干预措施将具有成本效益。当将干预措施扩展到低传统风险群体时，ICER为AUD$43,746，具有45％的成本效益概率。针对高传统黑色素瘤风险个体的基因组风险提供可能是减少晒伤的成本效益策略，可能预防未来的黑色素瘤和角质形成细胞癌。 版权所有 © 2023. Elsevier Inc. 发表。

Evidence indicates a melanoma prevention program using personalized genomic risk provision and genetic counselling, can impact prevention behaviors, including reducing sunburns in adults with no melanoma history. This analysis evaluated its longer-term cost-effectiveness from an Australian health system perspective.The primary outcome was incremental cost effectiveness ratio (ICER) of genomic risk provision (intervention) compared with standard prevention advice. A decision-analytic Markov model was developed using randomized trial data to simulate lifetime cost-effectiveness. All costs were presented in 2018/19 Australian dollars (AUD). The intervention effect on reduced sunburns was stratified by sex and traditional risk, which was calculated through a validated prediction model. Deterministic and probabilistic sensitivity analyses were undertaken for robustness checks.The per participant cost of intervention was AUD$189. Genomic risk provision targeting high-traditional risk individuals produced an ICER of AUD$35,254 (per QALY gained); sensitivity analyses indicated the intervention would be cost-effective in more than 50% of scenarios. When the intervention was extended to low-traditional risk groups, the ICER was AUD$43,746 with a 45% probability of being cost-effective.Genomic risk provision targeted to high-traditional melanoma risk individuals is likely a cost-effective strategy for reducing sunburns and will likely prevent future melanomas and keratinocyte carcinomas.Copyright © 2023. Published by Elsevier Inc.