(-)-大麻二酚是从大麻植物中提取的一类非精神活性植物类大麻素。目前，美国食品药品监督管理局已批准Epidiolex（大麻二酚）用于治疗两种罕见且严重的与癫痫相关的疾病，分别是Lennox-Gastaut综合症（LGS）和Dravet综合症（DS）。此外，大麻二酚及其结构类似物因其潜在的治疗效应，如神经保护、抗癫痫、抗炎、抗焦虑和抗癌等，而逐渐引起了人们的关注。根据文献综述，最近几年没有找到关于大麻二酚及其衍生物合成的综合性评论。因此，本文总结了已发表的大麻二酚合成方法和大麻二酚衍生物的合成途径，并介绍了一些被广泛研究并具有重要活性的大麻二酚类似物的生物活性。版权所有 © 2023 Elsevier Inc. 保留所有权利。

(-)-Cannabidiol is a class of non-psychoactive plant cannabinoids derived from cannabis plants. Currently, Epidiolex (Cannabidiol) has been approved by the FDA for the treatment of two rare and severe forms of epilepsy related diseases, namely Lennox-Gastaut syndrome (LGS) and Dravet (DS). In addition, Cannabidiol and its structural analogues have received increasing attention due to their potential therapeutic effects such as neuroprotection, anti-epilepsy, anti-inflammation, anti-anxiety, and anti-cancer. Based on literature review, no comprehensive reviews on the synthesis of Cannabidiol and its derivatives have been found in recent years. Therefore, this article summarizes the published synthesis methods of Cannabidiol and the synthesis routes of Cannabidiol derivatives, and introduces the biological activities of some Cannabidiol analogues that have been studied extensively and have significant activities.Copyright © 2023 Elsevier Inc. All rights reserved.