研究动态
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喉癌患者正桤淋巴结: 预测是否甲状腺转移?

Positive Delphian node in laryngeal cancer: Predictive of thyroid gland metastasis?

发表日期:2023 Aug 29
作者: Barbara Verro, Antonio Lo Casto, Carmelo Saraniti
来源: BIOMEDICINE & PHARMACOTHERAPY

摘要:

喉癌是全球第22常见癌症。喉癌转移至甲状腺极为罕见。总体上,转移性癌症对甲状腺腺体的侵犯在甲状腺恶性疾病中约占1.1-2.1%。一名70多岁的男性患者来到我们的耳鼻喉科单元,患有喉鳞状细胞癌(cT3)。进行了全喉切除术和双侧颈部淋巴结清扫术。组织学检查显示为pT3癌,颏间淋巴结亚肿大转移。患者接受了密切的随访。八个月后,颈部检查显示右甲状腺叶可疑结节。进行了右甲状腺叶切除术,组织学评估显示甲状腺叶上极存在鳞状细胞癌转移结节。剩余甲状腺组织受多发性大囊性结节性甲状腺肿影响。患者接受了辅助治疗。第二次手术后一年,未见复发迹象。喉癌转移至甲状腺是非常罕见的。根据文献,我们只发现了三篇文章描述了总共7例患有喉鳞状细胞癌的患者的甲状腺转移情况。阳性颏间淋巴结通常与预后不良相关:2007年的一项研究报告显示,在25例具有转移性颏间淋巴结的患者中,有15例在手术后的前两年内发生了肿瘤复发。喉癌转移至甲状腺是罕见的,所以必须对肿瘤患者进行密切随访,尤其是阳性颏间淋巴结不应低估其预测价值。 版权所有 © 2023 作者。由Elsevier Ltd.发布。保留所有权利。
Laryngeal carcinoma represents the 22nd most common cancer worldwide. Thyroid metastasis from laryngeal cancer is extremely rare. Overall, thyroid gland involvement by metastatic carcinoma represents about 1.1-2.1 % among thyroid malignant diseases.A male in his 70s came to our Otolaryngology Unit with a laryngeal squamous cell carcinoma (cT3). Total laryngectomy and bilateral neck dissection were performed. Histological examination revealed a pT3 carcinoma with sub-massive metastasis of the Delphian node. The patient underwent close follow-up. After eight months, neck examination revealed a suspected nodule in the right thyroid lobe. A right thyroid lobectomy was performed, and histological assessment revealed a nodule with squamous carcinoma metastasis in the superior pole of the thyroid lobe. The remaining thyroid tissue was affected by multinodular macrofollicular goitre. The patient underwent adjuvant therapy. One year after the second surgery, he showed no signs of recurrence.Thyroid gland metastasis from laryngeal carcinoma is a very rare occurrence. In literature, we found only three articles that describes thyroid metastasis in overall 7 patients affected by laryngeal squamous cell carcinoma. Positive Delphian lymph node is usually related to poor prognosis: in 2007 a study reported tumour recurrence in 15 out of 25 patients with metastatic Delphian lymph node within the first two years of surgery.Thyroid gland metastasis from laryngeal carcinoma is rare; so close follow-up of oncologic patients is mandatory and, most of all, the positive Delphian node should not be underestimated for its predictive value.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.