本文描述了一种基于装饰有Pd纳米颗粒的腔针石纳米管/碳复合材料（HNT/C @ Pd NPs）的有效生物传感平台。利用这种新型纳米平台设计了一种电化学适配体传感器，用于检测乳腺癌生物标志物——人表皮生长因子受体2（HER2）。由于HNT/C的高比表面积和Pd纳米颗粒沉积在HNT/C复合材料中所带来的良好导电性，自然而然地，适配体传感界面对肿瘤标志物具有高灵敏度和选择性。电化学适配体传感器的相关系数为0.996，线性范围从0.03 ng/mL到9 ng/mL。该方法的检测限（LOD）基于S/N=3方法为8 pg/mL。此外，设计的生物传感器表现出良好的选择性、良好的再现性和高稳定性。对该阻抗传感器在人血清样品中的适用性进行了检测，并与酶联免疫吸附测定（ELISA）方法进行了比较（p值>0.05）。根据结果发现，该方法可用于乳腺癌标志物的定量检测，用于早期诊断和治疗。版权所有 © 2023 Elsevier Inc.发布。

An effective biosensing platform is described based on halloysite nanotube/carbon composite decorated with Pd nanoparticles (HNT/C@Pd NPs). A novel electrochemical aptasensor was designed using the proposed nano-platform to determine human epidermal growth factor receptor 2 (HER2), a breast cancer biomarker. Inherently, aptasensing interfaces provide high sensitivity and selectivity for tumor markers owing to the high specific surface area of HNT/C and good conductivity stems from deposition of Pd NPs into HNT/C composite. With a correlation coefficient of 0.996, the electrochemical aptasensor demonstrated a wide linear range from 0.03 ng/mL to 9 ng/mL. The limit of detection (LOD) of the established assay was 8 pg/mL based on S/N = 3 method. Further, the designed biosensor demonstrated acceptable selectivity, good reproducibility, and high stability. The applicability of the impedimetric sensor in human serum samples was also examined and compared to enzyme-linked immunosorbent assay (ELISA) assay (p-value >0.05). Based on the results, it was found that the proposed methodology can be used in quantification of breast cancer markers for early diagnosis and treatment.Copyright © 2023. Published by Elsevier Inc.