乳腺癌是全球妇女中最常见的侵袭性恶性肿瘤，构成了一个复杂多样的疾病。近年来，人们对茴香烃受体(AhR)在乳腺癌中的作用以及环境污染的AhR激动剂的贡献产生了兴趣。在这里，我们提出了一篇文献综述，涉及AhR配体，包括杀虫剂六氯苯和氯毒死蜱，多环芳烃，多氯二苯并对二恶英和二苯并呋喃，多氯联苯，对羟基苯甲酸酯和邻苯二甲酸盐等。本综述的目标是a) 总结近期的原始实验、临床前和临床研究，探讨AhR激动剂干扰乳腺内分泌功能调节的生物机制；b) 研究AhR配体的生物影响及其对乳腺癌发生和发展的影响。我们讨论了细胞生存能力、细胞周期、增殖、表观遗传变化、上皮间质转化以及细胞迁移和侵袭方面的生物机制。此外，我们还研究了AhR配体对血管生成过程、转移、化疗抵抗和干细胞更新的影响。我们得出结论，暴露于AhR激动剂的途径刺激乳腺癌发展的途径，可能有助于肿瘤的进展。鉴于工业和农业化学品的大规模使用，对其在乳腺癌实验室检测和临床前研究中的影响进行持续评估，特别是在环境相关剂量下，被认为是必不可少的。同样，应该提高人们对最有害的毒物的意识，以消除或最小化其使用。Copyright©2023。由Elsevier Inc.发布。

Breast cancer is the most common invasive malignancy among women worldwide and constitutes a complex and heterogeneous disease. Interest has recently grown in the role of the aryl hydrocarbon receptor (AhR) in breast cancer and the contribution of environment-polluting AhR agonists. Here, we present a literature review addressing AhR ligands, including pesticides hexachlorobenzene and chlorpyrifos, polycyclic aromatic hydrocarbons, polychlorinated dibenzo-p-dioxins and dibenzofurans , polychlorinated biphenyls, parabens, and phthalates. The objectives of this review are a) to summarize recent original experimental, preclinical, and clinical studies on the biological mechanisms of AhR agonists which interfere with the regulation of breast endocrine functions, and b) to examine the biological effects of AhR ligands and their impact on breast cancer development and progression. We discuss biological mechanisms of action in cell viability, cell cycle, proliferation, epigenetic changes, epithelial to mesenchymal transition, and cell migration and invasion. In addition, we examine the effects of AhR ligands on angiogenic processes, metastasis, chemoresistance, and stem cell renewal. We conclude that exposure to AhR agonists stimulates pathways that promote breast cancer development and may contribute to tumor progression. Given the massive use of industrial and agricultural chemicals, ongoing evaluation of their effects in laboratory assays and preclinical studies in breast cancer at environmentally relevant doses is deemed essential. Likewise, awareness should be raised in the population regarding the most harmful toxicants to eradicate or minimize their use.Copyright © 2023. Published by Elsevier Inc.