雌激素受体阳性（HR+），人表皮生长因子阴性（HER2-）的乳腺癌，包括Luminal A和Luminal B亚型，在早期乳腺癌的女性中最常见。尽管筛查、手术和治疗方面取得了进展，但复发仍然发生。因此，及早发现那些显著影响复发风险的因素非常重要。基于目前的证据和专业知识，一组肿瘤学家讨论了早期乳腺癌复发高风险的定义。组织学分级、淋巴结受累、基因组评分、组织学分级、肿瘤大小和Ki-67增殖指数被评为定义早期乳腺癌患者高风险的最重要因素。所有这些因素都应该综合考虑，以根据每位患者的特殊特征选择治疗方案。版权所有 © 2023 Elsevier B.V. 发表。

Hormone-receptor positive (HR+), Human-Epidermal-growth Factor negative (HER2-) breast cancer, including the Luminal A and the Luminal B subtypes, is the most common in women diagnosed with early-stage BC. Despite the advances in screening, surgery and therapies, recurrence still occurs. Therefore, it is important to identify early those factors that significantly impact the recurrence risk. Based on current evidence and their professional expertise, a Panel of oncologists discussed the definition of high risk of recurrence in early breast cancer. Histological grade, nodal involvement, genomic score, histological grade, tumor size, and Ki-67 proliferation index were rated as the most important factors to define the high risk in patients with early breast cancer. All these factors should be considered comprehensively to tailor the choice of treatment to the peculiar characteristics of each patient.Copyright © 2023. Published by Elsevier B.V.