利用循环微生物DNA进行早期癌症检测。
Leveraging circulating microbial DNA for early cancer detection.
发表日期：2023 Aug 31
作者：
Radhika Kataria, Saeed Shoaie, Anita Grigoriadis, Jonathan C M Wan
来源：
Trends in Cancer
摘要：
微生物细胞内游离DNA（微生物cfDNA）提供了一种微创方法，用于对微生物组进行分析。尽管存在技术和生物学上的挑战，但利用深度测序、新颖的实验室方法和计算方法，评估微生物cfDNA在癌症检测方面的潜力的研究越来越多。利用液体活检来针对微生物组进行靶向治疗，有望改善早期癌症检测。版权所有 © 2023 作者。由Elsevier Inc.出版。保留所有权利。
Microbial cell-free DNA (microbial cfDNA) offers a minimally invasive approach for profiling the microbiome. Despite technical and biological challenges, the potential of microbial cfDNA for cancer detection is increasingly being evaluated using deep sequencing, novel laboratory approaches, and computational methods. Targeting the microbiome using liquid biopsies could improve early cancer detection.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.