在肿瘤和其他病理状态中，起着内皮细胞增殖、存活、血管生成和扩张的显著作用的血管生成素4（ANGPT4），是肿瘤血管生成的重要调节因子。许多癌细胞中ANGPT4的表达得到了增强。例如，ANGPT4的过表达促进了肺腺癌、胶质母细胞瘤和卵巢癌的形成、发展和进展。相关研究表明，ANGPT4可以促进肿瘤细胞的增殖、存活和侵袭，同时促进肿瘤血管系统的扩张，并影响肿瘤免疫微环境。ANGPT4还可以通过影响与免疫球蛋白样和表皮生长因子样结构域2（TIE2）和TIE2下游的酪氨酸激酶信号通路（如ERK1/2、PI3K/AKT）促进癌变。因此，ANGPT4可能是预测恶性肿瘤进展和不良结果的潜在和重要的生物标志物。此外，抑制ANGPT4可能是一种有意义的癌症治疗方法。本文回顾了ANGPT4在临床前研究中的最新研究结果，并强调了其在癌变过程中的作用。进一步研究ANGPT4的致癌功能可能为癌症生物学提供新的见解，并为癌症的诊断和治疗提供新方法。© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Angiopoietin4(ANGPT4) which plays a significant role in endothelial cell proliferation, survival, angiogenesis and expansion in tumors and other pathological states is a significant regulator of tumor angiogenesis. ANGPT4 expression is enhanced in many cancer cells. For example, the overexpression of ANGPT4 promotes the formation, development and progress of lung adenocarcinoma, glioblastoma and ovarian cancer. Related studies show that ANGPT4 encourages the proliferation, survival and invasion of tumor cells, while promoting the expansion of the tumor vascular system and affecting the tumor immune microenvironment. ANGPT4 can also promote carcinogenesis by affecting the ERK1/2, PI3K/AKT and other signal pathways downstream of tyrosine kinase with immunoglobulin-like and EGF-like domains 2(TIE2) and TIE2. Therefore, ANGPT4 may be a potential and significant biomarker for predicting malignant tumor progression and adverse outcomes. In addition, inhibition of ANGPT4 may be a meaningful cancer treatment. This paper reviews the latest research results of ANGPT4 in preclinical research, and emphasizes its role in carcinogenesis. Additional research on the carcinogenic function of ANGPT4 could provide new insights into cancer biology and novel methods for cancer diagnosis and treatment.© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.