RNA结合蛋白在肾细胞癌（RCC）的进展中起着重要的作用。然而，RBM47在RCC中的作用尚未阐明。本研究发现RBM47在RCC组织中下调表达，并且其表达与RCC患者的预后呈负相关。此外，我们发现RBM47的表达受CBP/P300介导的H3K27ac在RCC中的调控。功能上，RBM47抑制了RCC细胞的增殖和转移。机制上，RBM47通过直接与HOXB-AS1结合干扰了HOXB-AS1与p53蛋白的相互作用，最终促进了p53进入细胞核并激活了p53信号通路。此外，RBM47在体内和体外与舒尼替尼具有协同的抗癌效应。©2023年。细胞死亡分化协会（ADMC）。

RNA binding proteins have the critical role in renal cell carcinoma (RCC) progression. However, the role of RBM47 in RCC has not been elucidated. In this study, we found that RBM47 was downregulated in RCC tissues and its expression was negatively correlated with the prognosis of RCC patients. Also, we found that the expression of RBM47 was regulated by CBP/P300-mediated H3K27ac in RCC. Functionally, RBM47 restrained RCC cells proliferation and metastasis. Mechanistically, RBM47 interfered with the interaction between HOXB-AS1 and p53 proteins via directly binding with HOXB-AS1, finally promoted the entry of p53 into the nucleus and therefore activated the p53 signaling. Moreover, RBM47 had a synergistic anticancer effect with sunitinib both in vivo and in vitro.© 2023. Cell Death Differentiation Association (ADMC).