由于其酶特性，石墨炔素具有出色的潜力。无金属硫掺杂的石墨炔素（S-GDY）具有压电特性，对S-GDY进行超声激励可以增强过氧化酶活性。它能够将过氧化氢转化为有毒的羟基自由基，并在4T1细胞中诱导凋亡。更重要的是，超声增强的纳米酶能通过促进谷胱甘肽耗竭和谷胱甘肽过氧化物酶4失活导致不平衡的氧化还原反应，诱导4T1细胞发生铁死亡。S-GDY在体外和体内均表现出增强的纳米酶活性，可直接触发凋亡-铁死亡以实现有效的肿瘤治疗。总的来说，本研究有望为压电催化纳米酶的设计提供新的见解，拓展其在肿瘤催化治疗中的应用。© 2023年，Springer Nature旗下BioMed Central有限公司。

Graphdiyne has excellent potential due to its enzymatic properties. Metal-free sulfur-doped Graphdiyne (S-GDY) has piezoelectric characteristics, and ultrasonic excitation of S-GDY enhances peroxidase activity. It can turn hydrogen peroxide into toxic hydroxyl radicals and induce apoptosis in 4T1 cells. More importantly, the ultrasound (US) enhanced nanozyme induced 4T1 cell ferroptosis by promoting an imbalanced redox reaction due to glutathione depletion and glutathione peroxidase 4 inactivation. S-GDY exhibited enhanced nanozyme activity in vitro and in vivo that may directly trigger apoptosis-ferroptosis for effective tumor therapy. Altogether, this study was expected to provide new insights into the design of piezoelectric catalytic nanozyme and expand their application in the catalytic therapy of tumors.© 2023. BioMed Central Ltd., part of Springer Nature.