对于脑胶质母细胞瘤（GBM）患者，急需新型诊断和治疗策略。以往的研究表明，BCL2类13（BCL2L13）是BCL2家族的一个成员，调节不同类型肿瘤中的细胞生长和凋亡。然而，GBM中BCL2L13的临床意义、生物学作用和潜在机制尚未被探索。本研究显示BCL2L13在GBM细胞系和临床GBM组织样本中表达显著上调。在机制上，BCL2L13以Ser616位点靶向DNM1L，导致线粒体分裂和高位线粒体自噬通量。功能上，在体外和体内，这些改变显著促进了GBM细胞的增殖和侵袭。总体而言，我们的研究结果表明BCL2L13通过DNM1L介导的线粒体分裂在GBM中起着促进线粒体自噬的重要作用。因此，BCL2L13的调控和生物学功能使其成为治疗GBM的候选分子靶点。© 2023. 作者。

There is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family regulating cell growth and apoptosis in different types of tumors. However, the clinical significance, biological role, and potential mechanism in GBM remain unexplored. In this study, we showed that BCL2L13 expression is significantly upregulated in GBM cell lines and clinical GBM tissue samples. Mechanistically, BCL2L13 targeted DNM1L at the Ser616 site, leading to mitochondrial fission and high mitophagy flux. Functionally, these alterations significantly promoted the proliferation and invasion of GBM cells both in vitro and in vivo. Overall, our findings demonstrated that BCL2L13 plays a significant role in promoting mitophagy via DNM1L-mediated mitochondrial fission in GBM. Therefore, the regulation and biological function of BCL2L13 render it a candidate molecular target for treating GBM.© 2023. The Author(s).