肿瘤转移被认为是癌症相关死亡的主要原因。虽然临床应用药物已经证明可以有效去除原发肿瘤，但是转移瘤仍然较难到达。为了克服这一局限性，本文提出了一种治疗和诊断一体化纳米材料的开发，该纳米材料中融合了一个用于成像的染色体和一个用于治疗转移瘤的光敏剂。作用机制揭示了纳米颗粒能够通过光动力疗法局部产生细胞损伤，以及通过抑制对于肿瘤的发生、进展和转移至关重要的mTOR信号通路，从而系统地诱导免疫反应来干预。该纳米材料能够显著减小原发肿瘤的体积，并在女性小鼠的转移性乳腺癌和多药耐药的患者源性肝细胞癌模型中根除肿瘤转移。© 2023. Springer Nature Limited.

Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove the primary tumor, metastases remain poorly accessible. To overcome this limitation, herein, the development of a theranostic nanomaterial by incorporating a chromophore for imaging and a photosensitizer for treatment of metastatic tumor sites is presented. The mechanism of action reveals that the nanoparticles are able to intervene by local generation of cellular damage through photodynamic therapy as well as by systemic induction of an immune response by immunotherapy upon inhibition of the mTOR signaling pathway which is of crucial importance for tumor onset, progression and metastatic spreading. The nanomaterial is able to strongly reduce the volume of the primary tumor as well as eradicates tumor metastases in a metastatic breast cancer and a multi-drug resistant patient-derived hepatocellular carcinoma models in female mice.© 2023. Springer Nature Limited.