癌症对人类健康的严重威胁凸显了早期检测和有效治疗的重要性。近红外II区域荧光诊断与光热疗法的整合受到了关注，因其具有高灵敏度、快速响应和非侵入性。荧光是分子中电子的辐射弛豫过程产生的，而光热是分子中电子的非辐射弛豫过程产生的，二者是竞争的光物理过程。因此，分子在荧光和光热性质之间找到平衡是一项挑战。在本研究中，我们设计了一种带有TICT特性的近红外II区域半靛染料，利用带正电的吡啶盐和带负电的三苯胺作为电子受体和给体，并使用呋喃醇作为共轭的π-桥接物。合成的化合物中，HCY-995的量子产率为0.09%，光热转换效率为54.90%，并且具有显著的斯托克位移232 nm，适用于光热疗法和高分辨率成像的整合。这项研究为开发具有荧光和光热整合性质的近红外II区域分子提供了新的见解。本文章受版权保护，保留所有权利。

The serious threat that cancer poses to human health highlights the significance of early detection and effective treatment. The integration of fluorescence diagnosis and photothermal therapy in NIR-II has gained attention due to its high sensitivity, fast response, and non-invasiveness. Fluorescence, produced by the radiative relaxation process of electrons in a molecule, and photothermal, generated by the non-radiative relaxation process of electrons in a molecule, are competing photophysical processes. Hence, it is a challenge for the molecule to balance between the properties of fluorescence and photothermal. In this study, we designed a NIR-II hemicyanine with TICT character to obtain molecules with both better fluorescence and photothermal properties, utilizing positively charged pyridine salt and triphenylamine as electron acceptor and donor, respectively, and oxole as the conjugated π-bridge. HCY-995, one of the synthesized compounds, had a quantum yield of 0.09%, photothermal conversion efficiency of 54.90%, and a significant Stoke shift of 232 nm, which made it appropriate for the integration of photothermal therapy and high-resolution imaging. This study provides new insights into the development of NIR-II molecules with fluorescent and photothermal integrated properties. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.