为了评估高级前列腺癌(APC)骨转移中定量多参数全身MRI (mpWB-MRI) 参数的可重复性，使用1.5T MRI在同一天两次对10名APC患者进行检查。mpWB-MRI包括扩散加权成像(DWI)和T1加权梯度回波二点Dixon序列。分别计算了ADC和相对脂肪分数(rFF%)图。一名放射科医生对每项研究最多划定了10个靶骨转移灶。记录了每个目标病灶的ADC平均值、b900信号强度(SI)、归一化的b900 SI、rFF%和最大直径(MD)，以及每位患者所有目标的参数平均值。根据b900图像手工划定了全身疾病体积(tDV，以毫升为单位)，并计算出平均全局(g)ADC。进行了Bland-Altman分析，并计算了95%的重复性系数(RC)。共包含73个单个目标(中位MD为26毫米)。病灶平均ADC的RC为12.5%，平均b900 SI的RC为137%，归一化平均b900 SI的RC为110%，rFF%的RC为3.2%，目标MD的RC为5.5毫米(16.3%)。患者目标病灶平均ADC的RC为6.4%，b900 SI的RC为104%，归一化平均b900 SI的RC为39.6%。目标平均rFF%的RC为1.8%，平均MD的RC为1.3毫米(4.8%)。tDV分割的RC为6.4%，平均gADC的RC为5.3%。APC骨转移的ADC、rFF%和最大直径、tDV和gADC显示出良好的可重复性。APC骨转移的单个病灶和全身疾病体积的平均ADC和rFF%测量值可重复，支持它们作为转移性骨疾病的定量生物标志物的潜在作用。

To assess the repeatability of quantitative multiparametric whole-body MRI (mpWB-MRI) parameters in advanced prostate cancer (APC) bone metastases.1.5T MRI was performed twice on the same day in 10 APC patients. MpWB-MRI-included diffusion weighted imaging (DWI) and T1-weighted gradient-echo 2-point Dixon sequences. ADC and relative fat-fraction percentage (rFF%) maps were calculated, respectively. A radiologist delineated up to 10 target bone metastases per study. Means of ADC, b900 signal intensity(SI), normalised b900 SI, rFF% and maximum diameter (MD) for each target lesion and overall parameter averages across all targets per patient were recorded. The total disease volume (tDV in ml) was manually delineated on b900 images and mean global (g)ADC was derived. Bland-Altman analyses were performed with calculation of 95% repeatability coefficients (RC).Seventy-three individual targets (median MD 26 mm) were included. Lesion mean ADC RC was 12.5%, mean b900 SI RC 137%, normalised mean b900 SI RC 110%, rFF% RC 3.2 and target MD RC 5.5 mm (16.3%). Patient target lesion average mean ADC RC was 6.4%, b900 SI RC 104% and normalised mean b900 SI RC 39.6%. Target average rFF% RC was 1.8, average MD RC 1.3 mm (4.8%). tDV segmentation RC was 6.4% and mean gADC RC 5.3%.APC bone metastases' ADC, rFF% and maximum diameter, tDV and gADC show good repeatability.APC bone metastases' mean ADC and rFF% measurements of single lesions and global disease volumes are repeatable, supporting their potential role as quantitative biomarkers in metastatic bone disease.