DCLK1是一种树状细胞标记物，在各种肿瘤中广泛表达。其高表达水平与恶性肿瘤进展密切相关，使其成为潜在的与肿瘤相关的标记物。最近的研究揭示了DCLK1和树状细胞在免疫应答和上皮组织稳态维持中的关键作用，以及肿瘤微环境中的靶向免疫逃逸机制。本综述旨在全面审视DCLK1和树状细胞在上皮组织中介导的免疫相关功能，并讨论相关细胞和重要参与因子的作用。此外，本综述还将讨论由DCLK1/树状细胞介导的抗肿瘤免疫的最新进展及其作为免疫治疗靶点的潜力。此外，我们还将考虑DCLK1靶向治疗在癌症免疫治疗中的潜在影响，特别是DCLK1激酶抑制剂作为潜在治疗药物在抗肿瘤免疫中的潜力，为未来的研究提供新的视角和参考。版权所有©2023 Elsevier B.V.保留所有权利。

DCLK1, a tuft cell marker, is widely expressed in various tumors. Its high expression levels are closely linked to malignant tumor progression, making it a potential tumor-related marker. Recent studies have shed light on the critical roles of DCLK1 and tuft cells in the immune response and the maintenance of epithelial homeostasis, as well as targeted immune escape mechanisms in the tumor microenvironment. This review aims to comprehensively examine the current understanding of immune-related functions mediated by DCLK1 and tuft cells in epithelial tissues, including the roles of relevant cells and important factors involved. Additionally, this review will discuss recent advances in anti-tumor immunity mediated by DCLK1/tuft cells and their potential as immunotherapeutic targets. Furthermore, we will consider the potential impact of DCLK1 targeted therapy in cancer immunotherapy, particularly DCLK1 kinase inhibitors as potential therapeutic drugs in anti-tumor immunity, providing a new perspective and reference for future research.Copyright © 2023 Elsevier B.V. All rights reserved.