优化老年癌症患者的抗癌治疗和药物疗法需要采用多学科的方法，需要老年病学家、肿瘤学家和药师之间的密切合作。虽然所有患者都可以从中获益，但有些临床情况被认为是高优先级的。应特别关注心血管合并症和/或糖尿病患者，这些患者在抗癌治疗期间易出现失衡，并常涉及多种药物。另一个主要问题是摔倒的风险，这与多药物治疗密切相关，因此需要进行全面的药物评估。管理抗抑郁药物治疗也具有挑战性，需要共享专业知识。最后，药师在粘附困难或使用补充药物的情况下可以发挥重要作用。合作实践应该从抗癌治疗开始，并在整个护理过程中持续进行，因为持续进行的重新评估是必不可少的。尽管药师在多学科团队中的整合常受到资金的限制，但仍应强烈鼓励进行合作。版权所有 © 2023 Elsevier B.V.发表。

Optimizing anticancer treatment and medication therapy in older patients with cancer requires a multidisciplinary approach, with a strong collaboration between geriatricians, oncologists and pharmacists. While all patients can benefit, some clinical situations seem to be high-priority. Careful attention should be given to patients with cardiovascular comorbidities and/or diabetes, which are prone to decompensate during anticancer treatment and often involve multiple medications. Another great concern is the risk of falls, closely related to polypharmacy, hence the need for a comprehensive medication review. Managing the pharmacological treatment of depression is also challenging and require shared expertise. Finally, pharmacists can prove valuable in situations of adherence difficulties or use of complementary medicines. Collaborative practice should begin at initiation of anticancer treatment and continue throughout the care pathway, as continuous reassessment is essential. Although the integration of pharmacists in multidisciplinary teams is often challenged by funding, collaborative should still be strongly encouraged.Copyright © 2023. Published by Elsevier B.V.