本研究研究了DiffMag便携式探针（非线性磁测量）在哨兵淋巴结检测中的性能。此外，将DiffMag的性能与γ探针和一阶磁测量仪(Sentimag®, 线性磁测量)进行了比较。基于纵向距离、横向距离和两个示踪剂体积的分辨能力对所有三个探针的性能进行了评估。开发了一个模拟器来研究这些探针在口底（FOM）的临床相关情况下的性能。从纵向距离来看，DiffMag便携式探针和Sentimag®探针的性能相当，而γ探针能够检测到最少比它们深10倍的深度。对于小示踪剂体积，DiffMag便携式探针、Sentimag®和γ探针的横向距离分别为13、11和51毫米。而对于大示踪剂体积，分别为21、18和55毫米。在模拟器表面距离为7毫米的探针高度上，小示踪剂体积的半高宽分别为14、12和18毫米，而大示踪剂体积分别为15、18和25毫米。由于具有较高的分辨能力但纵向距离有限，DiffMag便携式探针似乎适用于检测与原发肿瘤密切相关的哨兵淋巴结。本研究表明，采用线性磁测量仪也能得到相似的结果。γ探针可达到较深的深度，但其分辨能力较DiffMag便携式探针较低。© 2023. 作者。

This study investigates the performance of the DiffMag handheld probe (nonlinear magnetometry), to be used for sentinel lymph node detection. Furthermore, the performance of DiffMag is compared with a gamma probe and a first-order magnetometer (Sentimag®, linear magnetometry).The performance of all three probes was evaluated based on longitudinal distance, transverse distance, and resolving power for two tracer volumes. A phantom was developed to investigate the performance of the probes for a clinically relevant situation in the floor of the mouth (FOM).Considering the longitudinal distance, both DiffMag handheld and Sentimag® probe had comparable performance, while the gamma probe was able to detect at least a factor of 10 deeper. Transverse distances of 13, 11, and 51 mm were measured for the small tracer volume by the DiffMag handheld, Sentimag®, and the gamma probe, respectively. For the large tracer volume this was 21, 18, and 55 mm, respectively. The full width at half maximum, at 7 mm probe height from the phantom surface, was 14, 12, and 18 mm for the small tracer volume and 15, 18, and 25 mm for the large tracer volume with the DiffMag handheld, Sentimag®, and gamma probe, respectively.With a high resolving power but limited longitudinal distance, the DiffMag handheld probe seems suitable for detecting SLNs which are in close proximity to the primary tumor. In this study, comparable results were shown using linear magnetometry. The gamma probe reached 10 times deeper, but has a lower resolving power compared with the DiffMag handheld probe.© 2023. The Author(s).