人类皮肤是人体中最广泛和最丰富的组织类型。随着时间的推移，我们的大部分器官，包括皮肤的相当一部分，都倾向于逐渐变薄或减小。随着年龄的增长，我们的皮肤的表皮和真皮层的厚度逐渐减少。这主要归因于表皮干细胞的衰退和真皮胶原蛋白的丧失，后者是人体中最丰富的蛋白质。皮肤的表皮和真皮层的年龄相关性变化影响皮肤的结构和功能，并创造出促进与年龄相关的皮肤疾病的组织微环境，如皮肤屏障功能受损、伤口愈合延迟和皮肤癌的发展。本综述将审查与皮肤表皮和真皮老化相关的当前文献。版权所有©2023日本皮肤病学研究学会。由Elsevier B.V.出版。保留所有权利。

Human skin is the most widespread and abundant type of tissue in the human body. With the passage of time, most of our organs, including a substantial part of the skin, tend to undergo a gradual thinning or decrease in size. As we age, there is a gradual and progressive reduction in the thickness of both the epidermis and dermis layers of our skin. This is primarily attributed to the decline of epidermal stem cells and the loss of dermal collagen, which is the most abundant protein in the human body. Age-related alterations of the epidermis and dermis impair skin structure/function and create a tissue microenvironment that promotes age-related skin diseases, such as impaired skin barrier, delayed wound healing, and skin cancer development. This review will examine the current body of literature pertaining to our knowledge of skin epidermal and dermal aging.Copyright © 2023 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.