细胞迁移诱导蛋白（CEMIP），也被称为KIAA1199和与透明质酸降解相关的透明质酸结合蛋白，是透明质酸酶家族的新成员，能降解透明质酸（HA）并重塑细胞外基质。近年来的研究表明，CEMIP可以促进各种肿瘤细胞的增殖、侵袭和粘附，并在细菌感染和关节炎中发挥重要作用。本综述聚焦于CEMIP在多种疾病中的病理机制，并从阻止细胞凋亡、促进HA降解、诱导炎症反应和相关磷酸化、调节细胞微环境以及调控组织纤维化等方面阐述了CEMIP的功能。对以CEMIP为靶点的诊断和治疗策略也进行了总结。CEMIP的多种功能展示了它巨大的潜在应用价值。版权所有 © 2023 刘、胡、李、孔、杨、李、劳、李、钟、张、冷、毕和翟。

Cell migration-inducing protein (CEMIP), also known as KIAA1199 and hyaluronan-binding protein involved in hyaluronan depolymerization, is a new member of the hyaluronidase family that degrades hyaluronic acid (HA) and remodels the extracellular matrix. In recent years, some studies have reported that CEMIP can promote the proliferation, invasion, and adhesion of various tumor cells and can play an important role in bacterial infection and arthritis. This review focuses on the pathological mechanism of CEMIP in a variety of diseases and expounds the function of CEMIP from the aspects of inhibiting cell apoptosis, promoting HA degradation, inducing inflammatory responses and related phosphorylation, adjusting cellular microenvironment, and regulating tissue fibrosis. The diagnosis and treatment strategies targeting CEMIP are also summarized. The various functions of CEMIP show its great potential application value.Copyright © 2023 Liu, Hu, Li, Kong, Yang, Li, Lao, Li, Zhong, Zhang, Leng, Bi and Zhai.