柚皮苷是一种天然的二氢黄酮，主要存在于芸香科柑橘属的柑橘类水果中，以及传统中药中的枳实、佛手、伞形科柚皮以及山奈等。现代药理学研究表明，柚皮苷具有出色的抗肿瘤活性。通过近年来对国内外相关文献的综述，我们总结了柚皮苷发挥抗癌作用的药理机制，包括阻断肿瘤细胞周期、抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移、诱导肿瘤细胞自噬、逆转肿瘤细胞药物抗性并增强化疗药物敏感性，以及抗炎作用以防止癌变，减轻化疗的不良药物反应，激活和增强免疫力。这为进一步探索柚皮苷的抗癌潜力以及其进一步开发和利用提供了理论基础和参考依据。版权所有 © 2023 He and Zhang.

Naringin is a kind of natural dihydro flavone, which mainly exists in citrus fruits of the Rutaceae family, as well as traditional Chinese medicines such as trifoliate orange, fingered citron, exocarpium citri grandis, and rhizoma dynamite. Modern pharmacological studies have shown that Naringin has excellent anti-tumor activity. Through reviewing the relevant literature at home and abroad in recent years, we summarized the pharmacological mechanism of Naringin to play an anti-cancer role in blocking tumor cell cycle, inhibiting tumor cell proliferation, inducing tumor cell apoptosis, inhibiting tumor cell invasion and metastasis, inducing tumor cell autophagy, reversing tumor cell drug resistance and enhancing chemotherapeutic drug sensitivity, as well as anti-inflammatory to prevent canceration, alleviate Adverse drug reaction of chemotherapy, activate and strengthen immunity, It provides theoretical basis and reference basis for further exploring the anticancer potential of Naringin and its further development and utilization.Copyright © 2023 He and Zhang.