线粒体功能障碍在不同肝脏疾病的发生和发展中起着重要作用。氧化磷酸化（OXPHOS）功能障碍和活性氧产生与线粒体功能障碍密切相关，迫使糖酵解成为肝细胞能量代谢的主要来源。此外，不同肝脏疾病中，尤其是肝癌中葡萄糖酵解也得到不同程度的增强。因此，以糖酵解信号通路为靶点提供了一种治疗非酒精性脂肪性肝病（NAFLD）和与肝癌相关的肝纤维化的新策略。天然产物调节糖酵解的许多步骤，以天然产物作为靶向糖酵解的治疗是一种有前景的抗癌治疗。在本综述中，我们主要阐明了糖酵解与肝病之间的关系，天然产物可以通过靶向糖酵解的关键酶及其相关蛋白来发挥作用，因此了解天然产物如何调节糖酵解有助于阐明这些药物抑制肝病的治疗机制。版权所有 © 2023 Li、Hao和Hu。

Mitochondrial dysfunction plays an important role in the occurrence and development of different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of reactive oxygen species are closely related to mitochondrial dysfunction, forcing glycolysis to become the main source of energy metabolism of liver cells. Moreover, glycolysis is also enhanced to varying degrees in different liver diseases, especially in liver cancer. Therefore, targeting the glycolytic signaling pathway provides a new strategy for the treatment of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis associated with liver cancer. Natural products regulate many steps of glycolysis, and targeting glycolysis with natural products is a promising cancer treatment. In this review, we have mainly illustrated the relationship between glycolysis and liver disease, natural products can work by targeting key enzymes in glycolysis and their associated proteins, so understanding how natural products regulate glycolysis can help clarify the therapeutic mechanisms these drugs use to inhibit liver disease.Copyright © 2023 Li, Hao and Hu.