细胞外囊泡（EVs），包括外泌体，在胃癌的发展和进展过程中发挥着至关重要的细胞间通信的作用，并成为重要的介体。本综述讨论了EVs，特别是外泌体lncRNA和microRNA在胃癌中的作用的当前理解，以及它们作为诊断和治疗靶标的潜力。外泌体是由肿瘤细胞和肿瘤微环境中的基质细胞分泌的小型膜结合颗粒。它们包含各种ncRNA和生物分子，可以传递给接受细胞以促进肿瘤生长和转移。在本综述中，我们强调了外泌体lncRNA和microRNA在胃癌中的重要性。已经表明外泌体lncRNA通过与转录因子或染色质修饰酶相互作用来调节基因表达，从而通过与靶向mRNA结合来调节基因表达。我们还讨论了外泌体lncRNA和microRNA作为胃癌诊断生物标志物的潜在用途。外泌体可以从包括血液、尿液和唾液在内的各种体液中分离出来。它们含有反映肿瘤分子特征的特定分子，使其成为非侵入性诊断测试的有前景的候选物。最后，本文还回顾了以外泌体lncRNA和microRNA为靶向的治疗策略在胃癌中的潜力。在临床前模型中已经证明，特定外泌体分子的抑制可以抑制肿瘤生长和转移。总之，本综述提供了外泌体lncRNA和microRNA在胃癌中作用的当前理解概述。我们建议进一步研究这些分子可能会为这种致命疾病提供新的诊断工具和治疗策略。 版权所有 © 2023 Jiang, Zhang, Wang, Shan, Sun, Tan, Tong and Qiu.

Extracellular vesicles (EVs), including exosomes, play a crucial role in intercellular communication and have emerged as important mediators in the development and progression of gastric cancer. This review discusses the current understanding of the role of EVs, particularly exosomal lncRNA and microRNA, in gastric cancer and their potential as diagnostic and therapeutic targets. Exosomes are small membrane-bound particles secreted by both cancer cells and stromal cells within the tumor microenvironment. They contain various ncRNA and biomolecules, which can be transferred to recipient cells to promote tumor growth and metastasis. In this review, we highlighted the importance of exosomal lncRNA and microRNA in gastric cancer. Exosomal lncRNAs have been shown to regulate gene expression by interacting with transcription factors or chromatin-modifying enzymes, which regulate gene expression by binding to target mRNAs. We also discuss the potential use of exosomal lncRNAs and microRNAs as diagnostic biomarkers for gastric cancer. Exosomes can be isolated from various bodily fluids, including blood, urine, and saliva. They contain specific molecules that reflect the molecular characteristics of the tumor, making them promising candidates for non-invasive diagnostic tests. Finally, the potential of targeting exosomal lncRNAs and microRNAs as a therapeutic strategy for gastric cancer were reviewed as wee. Inhibition of specific molecules within exosomes has been shown to suppress tumor growth and metastasis in preclinical models. In conclusion, this review article provides an overview of the current understanding of the role of exosomal lncRNA and microRNA in gastric cancer. We suggest that further research into these molecules could lead to new diagnostic tools and therapeutic strategies for this deadly disease.Copyright © 2023 Jiang, Zhang, Wang, Shan, Sun, Tan, Tong and Qiu.