研究动态
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癌症患者男性的生育保护。咨询及生殖结果。

Fertility preservation in male cancer patients. Counseling and reproductive outcomes.

发表日期:2023
作者: Dana Kimelman, Andrea Torrens, Carla Bonelli, Rossana Sapiro
来源: Frontiers in Cell and Developmental Biology

摘要:

引言:癌症治疗的进步已经确定了患者存活率的提高。然而,这些挽救生命的治疗可能对生殖健康产生负面影响。为减少不育风险,已设计了不同的生殖保护策略。对于青春期后的男性来说,冷冻精子是黄金标准的生殖保护方法。本研究的主要目的是评估乌拉圭男性癌症幸存者在进行冷冻精子过程中的生育状态,并评估这些患者接受的生育保健咨询。方法:这是一项描述性、横断面的观察性研究。在1985年至2021年期间,对冷冻精子的男性癌症幸存者进行了一项调查,调查对象是乌拉圭唯一的精子库"Reprovita实验室与生物库"的中冷冻精子。结果:共有135名参与者回答了问卷调查。诊断时,患者的平均年龄为28.8±6.4岁。睾丸癌是最常见的癌症类型(64%)。仅有12%(n=15)在诊断时已经有了孩子。在接受癌症治疗后,接受调查的幸存者中,50%(n=62)试图怀孕,68%(n=42)自然怀孕成功。未能自然受孕的患者(n=11)使用了他们的冷冻样本,其中45.4%成功怀孕。大约86%(n=107)的幸存者认为生育保健咨询的时机是适当的,有97%认为能够保护生育能力的可能性非常重要。80%(n=101)的人接受了主治医生的建议,14%(n=18)的人向家人或朋友寻求了建议,4%(n=5)的人寻求了生育保健专家的建议。讨论:据我们所知,这是首项评估我国和地区男性癌症幸存者生育结果的研究。大多数接受调查的幸存者都认为生育保护是一项积极的措施,不论他们的生育结果如何,这反映了生育保护咨询作为年轻癌症患者未来生活质量最重要的方面。版权所有 © 2023 Kimelman, Torrens, Bonelli and Sapiro.
Introduction: Advances in cancer treatments have determined an increase in survival rates. However, these lifesaving therapies may have a negative impact on reproductive health. To diminish the infertility risk; different fertility preservation strategies have been designed. Sperm freezing is the gold standard fertility preservation method in the case of post-pubertal men. The main objective of this study is to evaluate the fertility status of Uruguayan male cancer survivors who have gone through sperm freezing, as well as to assess oncofertility counseling received by these patients. Methods: This is a descriptive, cross-sectional, observational, and transversal study. A survey was conducted on male cancer survivors who cryopreserved sperm between 1985 and 2021 in "Reprovita Lab and Biobank" which is the only sperm bank in this country. Results: One hundred thirty-five participants answered the survey. At the time of diagnosis, the mean age of patients was 28.8 ± 6.4 years old. Testicular was the most frequent type of cancer (64%). Only, 12% (n = 15) already had children at the time of diagnosis. Among the interviewed survivors, 50% (n = 62) attempted to conceive after cancer treatment, and 68% (n = 42) achieved natural pregnancy. Patients who did not achieve spontaneous conception (n = 11), used their cryopreserved samples, and 45.4% achieved pregnancy. About 86% (n = 107) of survivors believed that the timing of oncofertility referrals was appropriate and 97% considered that having the possibility of protecting their fertility was very important. Eighty percent (n = 101), were advised by their attending physicians, 14% (n = 18) sought advice from family members or friends, and 4% (n = 5) from oncofertility specialists. Discussion: To our knowledge, this is the first study evaluating the reproductive outcomes of male cancer survivors in our country and the region. Most of the interviewed survivors considered fertility preservation as a positive initiative, independent of their reproductive outcomes, reflecting the importance of fertility preservation counseling as one of the most important aspects for futurequality of life of young cancer patients.Copyright © 2023 Kimelman, Torrens, Bonelli and Sapiro.