胆管细胞癌（CCA）是一种具有高恶性的常见肿瘤之一。其发病率逐年增长，潜伏并容易转移，并且大多数患者在诊断时已经处于晚期。手术是治疗CCA的必要方法，但由于早期诊断率低和CCA的高恶性，其5年生存率仍然不理想。因此，探索CCA的分子机制以寻找可靠的生物标志物和有效的治疗靶点对于改善CCA的早期诊断和生存率至关重要。非编码RNA（ncRNA）是一类无蛋白质编码能力的RNA，主要包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）。近年来，大量证据表明，异常表达的ncRNA可以通过调节表观遗传、海绵miRNA调节靶基因表达和参与调节与癌症相关的信号通路等多种机制来调控CCA的发生和发展，为CCA的早期诊断、预后评估和治疗靶向提供了新的方法和思路。本文将回顾近年来调节CCA进展的lncRNA和circRNA的分子机制，并探讨它们在CCA中的潜在临床价值。© 2023 The Author(s). Published by IMR Press.

Cholangiocarcinoma (CCA) is one of the most common tumors with high malignancy. Its incidence is increasing year by year, and it is insidious and easily metastasized, and most patients are already in advanced stages when they are diagnosed. Surgery is an essential treatment for CCA, but the 5-year survival rate is still unsatisfactory due to the low early diagnosis rate and high malignancy of CCA. Therefore, exploring the molecular mechanisms of CCA to find reliable biomarkers and effective therapeutic targets is essential to improve the early diagnosis and survival rate of CCA. Non-coding RNA (ncRNA) is a class of RNA without protein-coding ability, mainly including microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). In recent years, numerous pieces of evidence have shown that aberrantly expressed ncRNAs can regulate the occurrence and development of CCA through various mechanisms such as mediating epigenetic, sponge miRNAs regulating the expression of target genes and participating in regulating cancer-related signaling pathways, which provides new approaches and ideas for early diagnosis, prognosis assessment and therapeutic targeting of CCA. In this paper, we review the molecular mechanisms of lncRNAs and circRNAs regulating the progression of CCA in recent years and discuss their potential clinical value in CCA.© 2023 The Author(s). Published by IMR Press.