中心体是一种细胞质内的细胞器，具有微管组织的功能，同时也被认为是细胞信号传导的中枢。中心体的一些成分对DNA损伤响应的完全激活是必需的。然而，中心体是否调节特定的DNA修复通路尚不清楚。在这里，我们展示了中心体的存在对于完全激活重组是必需的，特别是对于授权其初始步骤即所谓的DNA末端剪切的完全授权是必需的。此外，我们确定了中心体结构的亚末端附属物和特定因子CEP170作为调节重组和剪切的关键中心体成分。因此，缺乏中心体或CEP170缺失的细胞对于DNA损伤剂具有高度敏感性。此外，多种癌症类型中CEP170的低水平与特定突变标志物的突变负担增加和较好的预后相关，这表明CEP170的变化可以作为突变驱动因子，但也可以成为改善当前肿瘤治疗的靶点。© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

The centrosome is a cytoplasmic organelle with roles in microtubule organization that has also been proposed to act as a hub for cellular signaling. Some centrosomal components are required for full activation of the DNA damage response. However, whether the centrosome regulates specific DNA repair pathways is not known. Here, we show that centrosome presence is required to fully activate recombination, specifically to completely license its initial step, the so-called DNA end resection. Furthermore, we identify a centriolar structure, the subdistal appendages, and a specific factor, CEP170, as the critical centrosomal component involved in the regulation of recombination and resection. Cells lacking centrosomes or depleted for CEP170 are, consequently, hypersensitive to DNA damaging agents. Moreover, low levels of CEP170 in multiple cancer types correlate with an increase of the mutation burden associated with specific mutational signatures and a better prognosis, suggesting that changes in CEP170 can act as a mutation driver but could also be targeted to improve current oncological treatments.© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license.