副标题：皮肤鳞状细胞癌中的肿瘤萌芽：一种新的预后风险因素。 摘要：肿瘤萌芽是指在肿瘤组织边缘出现的单个或少量的分离细胞或小团块。近年来，研究表明肿瘤萌芽在皮肤鳞状细胞癌的发展和预后中起着重要作用。本文旨在系统综述有关皮肤鳞状细胞癌中肿瘤萌芽作为一种新的预后风险因素的研究进展。 关键词：肿瘤萌芽、皮肤鳞状细胞癌、预后、风险因素、综述
Tumour budding in cutaneous squamous cell carcinoma: A novel prognosis risk factor.
发表日期：2023 Sep 04
作者：
Loreto Heredia, Pablo Vargas-Mora, Catalina Jahr, José Herranz, Pedro Ferrer-Rosende
来源：
Cell Death & Disease
摘要：
大多数皮肤鳞状细胞癌（cSCC）预后良好，但有一小部分患者会发生转移和死亡，对其风险评估仍然有争议。肿瘤脱落是一种组织学侵袭模式，在其他实体肿瘤中已成为新兴的危险因素。本研究旨在研究肿瘤脱落与cSCC中其他已知高危预测因子的关联性，以及肿瘤脱落对总体生存（OS）和疾病特异性生存（DSS）的影响。采用回顾性研究设计，纳入2010年至2020年间在一所大学医院行非生殖器cSCC切除活检诊断的患者，由病理学家重新分析组织学片，并评估脱落情况。采用单变量和多变量分析研究相关性。共检出156例cSCC活检，脱落呈阳性的占13.5％，与较差的DSS和OS相关。单变量分析显示，脱落与肿瘤直径、厚度、组织学分级、浸润程度、神经外和淋巴血管浸润、放疗史、复发性肿瘤和淋巴结转移（LNM）相关。多变量分析显示，脱落与恶性程度高的肿瘤、放疗史和LNM相关。这些结果表明在cSCC中，肿瘤脱落与大多数已知的危险因素相关。我们发现脱落存在与LNM、OS和DSS不良预后相关的证据。这支持了之前的研究结果，表明脱落可能与高危cSCC相关。© 2023 Australasian College of Dermatologists.
Most cutaneous squamous cell carcinomas (cSCC) have a good prognosis, there is a small group where metastasis and death occur and the evaluation of this risk is still cause for controversy. Tumour budding is a pattern of histological invasion that is an emerging risk factor in other solid tumours.To examine the association between tumour budding and other known high-risk predictors in cSCC. In addition, the impact of tumour budding on overall survival (OS) and disease-specific survival (DSS) was analysed.Retrospective study. It included patients with a diagnosis of non-genital cSCC by excisional biopsy at a university hospital, between 2010 and 2020. A pathologist re-analysed their histological slides and evaluated budding. Univariate and multivariate analyses were made to study the associations.156 cSCC biopsies were found, and positive tumour budding was found in 13.5%. This correlated with worse DSS and OS. On univariate analysis, budding was correlated with the diameter, thickness of the tumour, histological grade, level of invasion, perineural and lymphovascular invasion, previous radiotherapy, recurrent tumours and lymph node metastasis (LNM). Multivariate analysis: tumour budding was associated with poorly differentiated tumours, prior radiotherapy and LNM.An association was found between tumour budding and most known risk factors in cSCC. We found findings that indicate that the presence of tumour budding is associated with a worse prognosis in terms of LNM, OS and DSS. This supports the results of previous work which has suggested that budding could be related to high-risk cSCC.© 2023 Australasian College of Dermatologists.