在台湾人口中，使用面包消费估计进行对苯并苯酮衍生物的饮食风险评估。
Dietary risk assessment of benzophenone derivatives using bread consumption estimates in a Taiwanese population.
发表日期：2023 Sep 04
作者：
Hsin-Chang Chen, Chung-Jung Tsai, Yu-Fang Huang, Chen-Ting Wu
来源：
Food & Function
摘要：
苯甲酮（BP）及其九个类似物（BPs）被列为内分泌干扰物，是一种新兴的污染物类别。已有多项研究调查了从紫外线墨水到食品中的BPs迁移；然而，少有研究调查这些物质在食品中的存在以及对人类暴露的风险。我们验证了一种用于同时测定10种BPs（包括BP，BP-1，BP-2，BP-3，BP-8，4-MBP，2-OHBP，4-OHBP，M2BB和PBZ）的痕量和多残留方法。采用稳定同位素标记和超高效液相色谱-电喷雾离子化串联质谱法结合固液萃取法，对81个面包样品进行了分析。我们利用蒙特卡洛模拟法确定了从日常食用面包中摄入的BPs的预估日摄入量、非癌风险和终身癌症风险（LTCRs）的七个年龄组。该方法表现出良好的线性关系（R2 ≥ 0.991）、低检测限（0.04-2 ng/g）和满意的精密度。日内和日间相对标准偏差范围分别为0.6%-9%和3%-20%。BP、4-MBP、2-OHBP、BP-1和BP-3分别在样品中检出率为97%、67%、59%、24%和23%。2-OHBP的平均（范围）值为18.3 (
Listed as endocrine-disrupting chemicals, benzophenone (BP) and its nine analogues (BPs) are an emerging group of contaminants. The migration of BPs from ultraviolet inks to food has been investigated in many studies; however, few studies have investigated BPs in foods and the risks of human exposure to BPs. We validated a trace and multi-residue method for simultaneously determining 10 BPs, including BP, BP-1, BP-2, BP-3, BP-8, 4-MBP, 2-OHBP, 4-OHBP, M2BB, and PBZ. Eighty-one bread samples were analyzed using stable isotope labeling and ultrahigh-performance liquid chromatography-electrospray ionization tandem mass spectrometry with solid-liquid extraction. We determined the estimated daily intake of BPs, non-cancer risks, and lifetime cancer risks (LTCRs) from daily bread consumption for seven age groups using a Monte Carlo simulation. The method demonstrated robust linearity (R2 ≥ 0.991), low limits of detection (0.04-2 ng/g), and satisfactory precision. The intra- and interday relative standard deviation ranges were 0.6%-9% and 3%-20%, respectively. BP, 4-MBP, 2-OHBP, BP-1, and BP-3 were detected in 97%, 67%, 59%, 24%, and 23% of the samples, respectively. 2-OHBP had the highest mean (range) value of 18.3 (